ArticleBrain research2009
Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats.
Article in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Transcriptional profiling of the anterior cingulate cortex and nucleus accumbens using a double-hit model of prenatal and adolescent alcohol exposure.Physiology & behavior · 2026Article
- Prenatal Exposure to Low Alcohol and Alcohol Motivation in the Offspring.Advances in experimental medicine and biology · 2026Review
- Effects of prenatal alcohol exposure on the olfactory system development.Frontiers in neural circuits · 2024Review
- Review
- Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA.Scientific reports · 2021Article
- Article
- Article
- Prenatal Alcohol Exposure as a Case of Involuntary Early Onset of Alcohol Use: Consequences and Proposed Mechanisms From Animal Studies.Frontiers in behavioral neuroscience · 2020Article
- Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats.Frontiers in behavioral neuroscience · 2020Article
- Targeting the alternative sigma factor RpoN to combat virulence in Pseudomonas aeruginosa.Scientific reports · 2017Article
- Prenatal alcohol exposure selectively enhances young adult perceived pleasantness of alcohol odors.Physiology & behavior · 2015Article
- Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats.PloS one · 2014Article
- Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets.Brain sciences · 2013Article
- Impaired odor identification in children with histories of heavy prenatal alcohol exposure.Alcohol (Fayetteville, N.Y.) · 2013Article
- Fetal nicotine exposure increases preference for nicotine odor in early postnatal and adolescent, but not adult, rats.PloS one · 2013Article
- Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.Structure (London, England : 1993) · 2011Article
- Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice.Molecular brain · 2011Article
- Focus on: neurotransmitter systems.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2011Review
- The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats.Alcoholism, clinical and experimental research · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Fetal exposure to ethanol is highly predictive of the propensity to ingest ethanol during adolescence and in utero chemosensory plasticity has been implicated as a contributing factor in this process. Recent rodent studies have shown that fetal ethanol exposure results in a tuned unconditioned sniffing and neurophysiological olfactory response to ethanol odor in infant animals. Importantly, a significant proportion of increased ethanol avidity at this age can be attributed to the tuned behavioral response to ethanol odor. These effects are absent in adults. Using behavioral methods and comprehensive gene expression profiling to screen for robust transcriptional differences induced in the olfactory bulb, we examined whether ethanol exposure via maternal diet results in an altered responsiveness to ethanol odor that persists into late adolescence and, if so, the molecular mechanisms that may be associated with such effects. Compared to controls, fetal exposure altered: the adolescent sniffing response to ethanol odor consistent with the previously observed changes in infant animals; and the expression of genes involved in synaptic transmission and plasticity as well as neuronal development (both cell fate and axon/neurite outgrowth). These data provide evidence for a persistence of olfactory-mediated responsiveness to ethanol into the period of adolescence. Further, they provide insight into an important relationship between fetal exposure to ethanol, adolescent odor responsiveness to the drug and potential underlying molecular mechanisms for the odor-guided behavioral response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.