ArticleClinical and experimental immunology1991
Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes.
Article in Clinical and experimental immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Circulating cytokine levels in patients with rheumatoid arthritis: results of a double blind trial with sulphasalazine.Annals of the rheumatic diseases · 1992Trial
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- Differences of the Structure of Immune Regulatory Cell Populations between Cellular Material from Sonographically Detected Focal Thyroid Lesions and Peripheral Blood in Humans.International journal of molecular sciences · 2019Article
- The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2.Molecules (Basel, Switzerland) · 2018Article
- Novel Therapeutic Targets in Axial Spondyloarthritis.Current treatment options in rheumatology · 2018Review
- Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner.Cellular & molecular immunology · 2017Article
- Effect of Mucosal Cytokine Administration on Selective Expansion of Vaginal Dendritic Cells to Support Nanoparticle Transport.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Article
- Functional Starters for Functional Yogurt.Foods (Basel, Switzerland) · 2015Article
- Hematopoietic colony-stimulating factors: new players in tumor-nerve interactions.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with Brucella abortus.Infection and immunity · 2011Article
- Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain.Nature medicine · 2009Article
- Proinflammatory response of human osteoblastic cell lines and osteoblast-monocyte interaction upon infection with Brucella spp.Infection and immunity · 2009Article
- The pattern of cytokine gene expression in human colorectal carcinoma.Pathology oncology research : POR · 2004Article
- Interleukin-1beta mediates endotoxin- and tumor necrosis factor alpha-induced RGS16 protein expression in cultured cardiac myocytes.Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis.Infection and immunity · 2001Article
- Article
- Immunoglobulin A1 protease, an exoenzyme of pathogenic Neisseriae, is a potent inducer of proinflammatory cytokines.The Journal of experimental medicine · 1999Article
- Production of granulocyte-macrophage colony-stimulating factor by T cells is regulated by B7 and IL-1 beta.Immunology · 1996Article
- Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism.Clinical and experimental immunology · 1995Article
- A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.The Journal of clinical investigation · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of GM-CSF, IL-2, IFN-gamma, TNF-alpha and IL-6 on the production of IL-1 (both secreted and cell associated) and TNF-alpha by peripheral blood monocytes were studied. Monocytes were cultured for 20 h in suspension and in serum-free conditions which minimized background stimulation of monokine production. GM-CSF, IL-2 and TNF-alpha directly induced the production of cell-associated IL-1 but little or no IL-1 or TNF-alpha secretion. Combination of GM-CSF with IFN-gamma, IL-2 or TNF-alpha synergistically enhanced IL-1 secretion and had an additive effect on cell-associated IL-1 production. Combination of IL-2 with IFN-gamma or TNF-alpha also synergistically enhanced IL-1 secretion but the effect on cell-associated IL-1 production was less than additive. GM-CSF synergistically enhanced TNF-alpha secretion induced by IFN-gamma but not by lipopolysaccharide. GM-CSF did not enhance TNF-alpha secretion induced by IL-2 or TNF-alpha. In contrast, IL-2 synergistically enhanced TNF-alpha secretion induced by IFN-gamma. These results are discussed in relation to cytokine involvement in rheumatoid arthritis.
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