ReviewCurrent allergy and asthma reports2009
Fixed drug eruption: a prototypic disorder mediated by effector memory T cells.
Review in Current allergy and asthma reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- Oral Site-Specific Patch Testing Directly at the Fixed Drug Eruption Site in Drug Allergy Investigation.Contact dermatitis · 2026Article
- Etoricoxib-Induced Fixed Erythema.Journal of clinical medicine · 2025Article
- Consistently Reproducible Fixed Drug-induced Urticaria in a Patient with Metastatic Melanoma Under Immunotherapy.Acta dermato-venereologica · 2025Article
- Tissue-resident memory T cells and their function in skin diseases.Chinese medical journal · 2025Review
- Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2024Article
- Fixed drug eruption-induced balanoposthitis: a case report.International journal of impotence research · 2024Article
- Severe cutaneous adverse reactions.Nature reviews. Disease primers · 2024Review
- Nimesulide-Induced Fixed Drug Eruption Followed by Etoricoxib-Induced Fixed Drug Eruption: An Unusual Case Report and Review of the Literature.Journal of clinical medicine · 2024Review
- Mucosal Fixed Drug Eruption with Oral, Conjunctival, Nasal, and Anal Lesions: A Case Report.Acta dermato-venereologica · 2023Article
- Chlorthalidone-Induced Fixed-Drug Eruption: Unmasking an Uncommon Reaction to a Common Diuretic.Cureus · 2023Article
- Fixed Drug Eruptions With Flavoured Liquid Formulations of Over-the-Counter Analgesics: A Case Report.Cureus · 2023Article
- Article
- Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders.Cellular & molecular immunology · 2020Review
- Drug desensitization in allergic children.Acta bio-medica : Atenei Parmensis · 2019Review
- Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects.The Journal of clinical and aesthetic dermatology · 2017Article
- Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.The American journal of case reports · 2016Article
- Drug allergy: causes and desensitization.Human vaccines & immunotherapeutics · 2012Review
- Mucosal fixed drug eruption in a patient treated with ornidazole.Journal of dermatological case reports · 2012Article
- Fixed Drug Eruption to Levocetirizine Detected by Patch Testing.Indian dermatology online journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effector memory T cells are uniquely specialized to mediate protective immunity. However, their excessive activation may result in the development of organ-specific inflammatory diseases, which have not been extensively studied. Fixed drug eruption (FDE), a localized variant of drug-induced dermatoses characterized by relapse in the same location, is a prototypic disorder mediated by excessive activation of effector memory T cells, which are resident in the lesional epidermis. A variety of clinical and pathologic features uniquely observed in FDE lesions can be explained by the presence of CD8(+) intraepidermal T cells with the effector memory phenotype in the FDE lesion. This review focuses on how these T cells are generated, retained in the epidermis, and activated to cause epidermal damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.