ArticleCurrent allergy and asthma reports2009
Role of leukotrienes in exercise-induced bronchoconstriction.
Article in Current allergy and asthma reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Distinctive bronchial inflammation status in athletes: basophils, a new player.European journal of applied physiology · 2013Trial
- Trial
- An Algorithm for Strategic Continuation or Restriction of Asthma Medication Prior to Exercise Challenge Testing in Childhood Exercise Induced Bronchoconstriction.Frontiers in pediatrics · 2022Article
- Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.The European respiratory journal · 2020Article
- Function of secreted phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Infant rhinitis and watery eyes predict school-age exercise-induced wheeze, emergency department visits and respiratory-related hospitalizations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Lack of desensitization of the cough reflex in ovalbumin-sensitized rabbits during exercise.PloS one · 2017Article
- Exercise-Induced Bronchospasm and Allergy.Frontiers in pediatrics · 2017Review
- Exercise and asthma: an overview.European clinical respiratory journal · 2015Article
- Which biomarkers are effective for identifying Th2-driven inflammation in asthma?Current allergy and asthma reports · 2013Review
- Regulation and function of epithelial secreted phospholipase A2 group X in asthma.American journal of respiratory and critical care medicine · 2013Article
- Exercise-induced wheeze, urgent medical visits, and neighborhood asthma prevalence.Pediatrics · 2013Article
- Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner.Biochimica et biophysica acta · 2012Article
- New insights into pathogenesis of exercise-induced bronchoconstriction.Current opinion in allergy and clinical immunology · 2012Review
- An update on the role of leukotrienes in asthma.Current opinion in allergy and clinical immunology · 2010Review
- An update on exercise-induced bronchoconstriction with and without asthma.Current allergy and asthma reports · 2009Review
- Exercise-induced asthma: critical analysis of the protective role of montelukast.Journal of asthma and allergy · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. EIB occurs mainly in individuals with other features of asthma but is especially prominent in a subset of asthmatics with pronounced indirect airway hyperresponsiveness. Leukotrienes (LTs) play a critical role in the pathophysiology of EIB. Asthmatics who are susceptible to EIB have increased levels of cysteinyl LTs (cysLTs [ie, LTs C4, D4, and E4]) in induced sputum and exhaled breath condensate. Exercise challenge in individuals susceptible to this disorder initiates the sustained increase in cysLTs in the airways and an increase in the ratio of cysLTs to prostaglandin E(2). The effects of cysLTs leading to secreted mucin release and smooth muscle constriction may be mediated in part through activation of sensory nerves. Therapies that block cysLT production or the cysLT(1) receptor effectively reduce the severity of EIB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.