ReviewCurrent allergy and asthma reports2009
Genome-wide association studies in the genetics of asthma.
Review in Current allergy and asthma reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells.Scientific reports · 2019Article
- Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur children in Xinjiang.Experimental and therapeutic medicine · 2019Article
- Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population.Asia Pacific allergy · 2011Article
- Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population.BMC medical genetics · 2011Article
- Gene-environment interactions in chronic inflammatory disease.Nature immunology · 2011Review
- Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population.PloS one · 2011Article
- Immunological and genetic aspects of asthma and allergy.Journal of asthma and allergy · 2010Article
- Asthma and allergy: the emerging epithelium.Nature medicine · 2010Article
- Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.The Journal of allergy and clinical immunology · 2010Article
- Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.Immunology and cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of asthma genetics has progressed rapidly over the past decade, implicating many genes and variants in the etiology of this complex disease. However, many of these factors have failed to replicate consistently, indicating a high false-positive rate and/or insufficient power for the detection of small effects. Technological limitations also have restricted the potential to detect novel mechanisms, fostering a dependence on existing knowledge. Since its inception almost 4 years ago, genome-wide association (GWA) has transformed genetic studies of multifactorial traits and yielded unprecedented insights into mechanisms of causation. Asthma is at the forefront of this revolution, as it uses GWA to map not only genetic determinants of clinical status but also transcript and protein abundance and structural (copy number) variants that may underlie disease susceptibility. In this review, we consider the applications of GWA data to asthma and describe the factors likely to influence the procedure's success.
Indexed as
Identifiers
19063818What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.