ArticleBMC bioinformatics2008
Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases.
Article in BMC bioinformatics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
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- Universal concept signature analysis: genome-wide quantification of new biological and pathological functions of genes and pathways.Briefings in bioinformatics · 2020Article
- BEERE: a web server for biomedical entity expansion, ranking and explorations.Nucleic acids research · 2019Article
- ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci.Nucleic acids research · 2019Article
- MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women.PloS one · 2019Article
- MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization.BMC bioinformatics · 2018Article
- A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2018Article
- Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis.BMC medical genomics · 2017Article
- GenePANDA-a novel network-based gene prioritizing tool for complex diseases.Scientific reports · 2017Article
- Arete - candidate gene prioritization using biological network topology with additional evidence types.BioData mining · 2017Article
- Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems.Journal of proteome research · 2016Article
- Enhancing Interpretability of Gene Signatures with Prior Biological Knowledge.Microarrays (Basel, Switzerland) · 2016Article
- Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery.Briefings in bioinformatics · 2016Review
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- A guide on gene prioritization in studies of psychiatric disorders.International journal of methods in psychiatric research · 2015Review
- Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome.Journal of translational medicine · 2015Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMillions of single nucleotide polymorphisms have been identified as a result of the human genome project and the rapid advance of high throughput genotyping technology. Genetic association studies, such as recent genome-wide association studies (GWAS), have provided a springboard for exploring the contribution of inherited genetic variation and gene/environment interactions in relation to disease. Given the capacity of such studies to produce a plethora of information that may then be described in a number of publications, selecting possible disease susceptibility genes and identifying related modifiable risk factors is a major challenge. A Web-based application for finding evidence of such relationships is key to the development of follow-up studies and evidence for translational research. We developed a Web-based application that selects and prioritizes potential disease-related genes by using a highly curated and updated literature database of genetic association studies. The application, called Gene Prospector, also provides a comprehensive set of links to additional data sources.
resultsWe compared Gene Prospector results for the query "Parkinson" with a list of 13 leading candidate genes (Top Results) from a curated, specialty database for genetic associations with Parkinson disease (PDGene). Nine of the thirteen leading candidate genes from PDGene were in the top 10th percentile of the ranked list from Gene Prospector. In fact, Gene Prospector included more published genetic association studies for the 13 leading candidate genes than PDGene did.
conclusionGene Prospector provides an online gateway for searching for evidence about human genes in relation to diseases, other phenotypes, and risk factors, and provides links to published literature and other online data sources. Gene Prospector can be accessed via http://www.hugenavigator.net/HuGENavigator/geneProspectorStartPage.do.
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