ArticleHead & face medicine2008
Behavior of osteoblastic cells cultured on titanium and structured zirconia surfaces.
Article in Head & face medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 123 citations in OpenAlex.
- Meso-Scale Modifications in Additively Manufactured Zirconia: Topographical Design and Its Influence on Cell-Material Interactions.Bioengineering (Basel, Switzerland) · 2026Article
- In Vitro and In Vivo Evaluation of Yttria-Niobia-Stabilized Zirconia Sandblasted Surface at Bone-Implant Interface with 3-Dimensional Visualization via Advanced Hard Tissue Clearing.Biomaterials research · 2026Article
- Assessment of osseointegration mechanisms in a novel zirconia implant: From experimental insights to clinical comparison.Journal of dental sciences · 2026Article
- Zirconia in Dental Implantology: A Review of the Literature with Recent Updates.Bioengineering (Basel, Switzerland) · 2025Review
- Modulated-Diameter Zirconia Nanotubes for Controlled Drug Release-Bye to the Burst.Journal of functional biomaterials · 2025Article
- Effect of acid etching and sandblasting on the osseointegration potential of implants.Bioinformation · 2025Article
- Development of a Coculture Model for Assessing Competing Host Mammalian Cell and Bacterial Attachment on Zirconia versus Titanium.ACS biomaterials science & engineering · 2024Article
- Article
- The Impact of Mechanical Debridement Techniques on Titanium Implant Surfaces: A Comparison of Sandblasted, Acid-Etched, and Femtosecond Laser-Treated Surfaces.Journal of functional biomaterials · 2023Article
- Drug infused AlProgress in biomaterials · 2022Article
- Surface modification of zirconia dental implants by laser texturing.Lasers in medical science · 2022Review
- Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing.Pharmaceutics · 2021Article
- Biofunctionalization of Dental Abutment Surfaces by Crosslinked ECM Proteins Strongly Enhances Adhesion and Proliferation of Gingival Fibroblasts.Advanced healthcare materials · 2021Article
- Biological and microbiological interactions of Ti-35Nb-7Zr alloy and its basic elements on bone marrow stromal cells: good prospects for bone tissue engineering.International journal of implant dentistry · 2020Article
- Effects of Plasma Treatment on the Bioactivity of Alkali-Treated Ceria-Stabilised Zirconia/Alumina Nanocomposite (NANOZR).International journal of molecular sciences · 2020Article
- Sprayed cultured autologous keratinocytes in the treatment of severe burns: a retrospective matched cohort study.Annals of burns and fire disasters · 2020Article
- Biological characterization of surface-treated dental implant materials in contact with mammalian host and bacterial cells: titaniumRSC advances · 2019Article
- Biomechanical and Histological Analysis of Titanium (Machined and Treated Surface) Versus Zirconia Implant Materials: An In Vivo Animal Study.Materials (Basel, Switzerland) · 2019Article
- Osteoclastogenesis Behavior of Zirconia for Dental Implant.Materials (Basel, Switzerland) · 2019Article
- Osseointegration of Alkali-Modified NANOZR Implants: An In Vivo Study.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsseointegration is crucial for the long-term success of dental implants and depends on the tissue reaction at the tissue-implant interface. Mechanical properties and biocompatibility make zirconia a suitable material for dental implants, although surface processings are still problematic. The aim of the present study was to compare osteoblast behavior on structured zirconia and titanium surfaces under standardized conditions.
methodsThe surface characteristics were determined by scanning electron microscopy (SEM). In primary bovine osteoblasts attachment kinetics, proliferation rate and synthesis of bone-associated proteins were tested on different surfaces.
resultsThe results demonstrated that the proliferation rate of cells was significantly higher on zirconia surfaces than on titanium surfaces (p < 0.05; Student's t-test). In contrast, attachment and adhesion strength of the primary cells was significant higher on titanium surfaces (p < 0.05; U test). No significant differences were found in the synthesis of bone-specific proteins. Ultrastructural analysis revealed phenotypic features of osteoblast-like cells on both zirconia and titanium surfaces.
conclusionThe study demonstrates distinct effects of the surface composition on osteoblasts in culture. Zirconia improves cell proliferation significantly during the first days of culture, but it does not improve attachment and adhesion strength. Both materials do not differ with respect to protein synthesis or ultrastructural appearance of osteoblasts. Zirconium oxide may therefore be a suitable material for dental implants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.