ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2009
Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Four pleiotropic loci associated with fat mass and lean mass.International journal of obesity (2005) · 2020Pooled it
- Review
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
- Muscle-bone crosstalk and potential therapies for sarco-osteoporosis.Journal of cellular biochemistry · 2019Review
- Estimating body mass and composition from proximal femur dimensions using dual energy x-ray absorptiometry.Archaeological and anthropological sciences · 2019Article
- Heritability of muscle mass in Korean parent-offspring pairs in the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V).Maturitas · 2018Article
- Relationship between body mass, lean mass, fat mass, and limb bone cross-sectional geometry: Implications for estimating body mass and physique from the skeleton.American journal of physical anthropology · 2018Article
- The genetics of bone mass and susceptibility to bone diseases.Nature reviews. Rheumatology · 2016Review
- Review
- Endocrine crosstalk between muscle and bone.Current osteoporosis reports · 2014Review
- Bone and Muscle Pleiotropy: The Genetics of Associated Traits.Clinical reviews in bone and mineral metabolism · 2014Article
- Advances in osteoarthritis genetics.Journal of medical genetics · 2013Review
- Bone and skeletal muscle: neighbors with close ties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Review
- Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.Human genetics · 2013Article
- Genes and the ageing muscle: a review on genetic association studies.Age (Dordrecht, Netherlands) · 2013Review
- Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Genetic aspects of skeletal muscle strength and mass with relevance to sarcopenia.BoneKEy reports · 2012Review
- The genetic pleiotropy of musculoskeletal aging.Frontiers in physiology · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
The risk of osteoporotic fracture is a function of both applied muscle mass and bone tissue distribution. Leg lean mass (LLM) and femoral bone geometry are both known to have substantial genetic components. Therefore, we estimated shared heritability (h(2)) and performed linkage analysis to identify chromosomal regions governing both LLM and bone geometry. A genome-wide scan (using 636 microsatellite markers) for linkage analyses was performed on 1346 adults from 327 extended families of the Framingham study. DXA measures were LLM, femoral neck length, neck-shaft angle (NSA), subperiosteal width, cross-sectional area (CSA), and section modulus (Z) at the femoral narrow neck and shaft (S) regions. Variance component linkage analysis was performed on normalized residuals (adjusted for age, height, BMI, and estrogen status in women). The results indicated substantial h(2) for LLM (0.42 +/- 0.07) that was comparable to bone geometry traits. Phenotypic correlations between LLM and bone geometry phenotypes ranged from 0.033 with NSA (p > 0.05) to 0.251 with S_Z (p < 0.001); genetic correlations ranged from 0.087 (NSA, p > 0.05) to 0.454 (S_Z, p < 0.001). Univariate linkage analysis of covariate-adjusted LLM identified no chromosomal regions with LOD scores >or=2.0; however, bivariate analysis identified two loci with LOD scores >3.0, shared by LLM with S_CSA on chromosome 12p12.3-12p13.2, and with NSA, on 14q21.3-22.1. In conclusion, we identified chromosomal regions potentially linked to both LLM and femoral bone geometry. Identification and subsequent characterization of these shared loci may further elucidate the genetic contributions to both osteoporosis and sarcopenia.
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