ArticleChemical research in toxicology2009
Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.
Article in Chemical research in toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 81 citations in OpenAlex.
- Review
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- Therapeutic Potential of 4-Hexylresorcinol in Preserving Testicular Function in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2024Article
- Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats.International journal of molecular sciences · 2021Article
- Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies.Chemical research in toxicology · 2021Article
- Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.International journal of molecular sciences · 2020Article
- Safety and efficacy of propyl gallate for all animal species.EFSA journal. European Food Safety Authority · 2020Article
- Article
- Effects of 4-Hexylresorcinol on Protein Expressions in RAW 264.7 Cells as Determined by Immunoprecipitation High Performance Liquid Chromatography.Scientific reports · 2019Article
- Ergot alkaloids: From witchcraft tillToxicology reports · 2015Article
- The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Endocrine disrupting effects of butylated hydroxyanisole (BHA - E320).Clujul medical (1957) · 2013Review
- NMR analysis reveals 17β-estradiol induced conformational change in ERβ ligand binding domain expressed in E. coli.Molecular biology reports · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In the search for xenoestrogens within food additives, we have analyzed the Joint FAO-WHO expert committee database, containing 1500 compounds, using an integrated in silico and in vitro approach. This analysis identified 31 potential estrogen receptor alpha ligands that were reduced to 13 upon applying a stringent filter based on ligand volume and binding mode. Among the 13 potential xenoestrogens, four were already known to exhibit an estrogenic activity, and the other nine were assayed in vitro, determining the binding affinity to the receptor and biological effects. Propyl gallate was found to act as an antagonist, and 4-hexylresorcinol was found to act as a potent transactivator; both ligands were active at nanomolar concentrations, as predicted by the in silico analysis. Some caution should be issued for the use of propyl gallate and 4-hexylresorcinol as food additives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.