ArticleThe Journal of infectious diseases2009
Quantitative trait loci associated with susceptibility to bladder and kidney infections induced by Escherichia coli in female C3H/HeJ mice.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genetic risk for recurrent urinary tract infections in humans: a systematic review.Journal of biomedicine & biotechnology · 2010Pooled it
- A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence.Nucleic acids research · 2022Article
- Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies.Microbiology and molecular biology reviews : MMBR · 2016Review
- Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice.Disease models & mechanisms · 2013Article
- Adenylate cyclase and the cyclic AMP receptor protein modulate stress resistance and virulence capacity of uropathogenic Escherichia coli.Infection and immunity · 2013Article
- Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.Scientific reports · 2013Article
- How to make it in the urinary tract: a tutorial by Escherichia coli.PLoS pathogens · 2012Review
- Article
- Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.PLoS pathogens · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe C3H/HeJ mouse strain develops severe bladder and kidney infections after receiving intravesical inoculation with uropathogenic Escherichia coli. This susceptibility is genetically determined, but the specific genes involved have not been completely defined. The objective of the present study was to use quantitative trait locus (QTL) mapping to identify chromosomal sites associated with susceptibility to infection in C3H/HeJ mice.
methodsFemale mice from a backcross of C3H/HeJ and (BALB/cxC3H/HeJ)F1 mice were inoculated with E. coli, and the number of E. coli colony-forming units present in the bladder and kidneys was quantified 10 days later. Genomic DNA was scanned using microsatellite markers to localize chromosomal segments derived from parental strains. Statistical analyses associated infection phenotypes with chromosomal sites.
resultsA highly significant QTL for susceptibility to bladder infection was identified on chromosome 4, and C3H/HeJ alleles at this locus interacted with BALB/c alleles on chromosome 19 to increase the severity of infection. A significant QTL on chromosome 6 was associated with severe kidney infections.
conclusionsIncreased susceptibility to E. coli bladder and kidney infections in female C3H/HeJ mice is associated with specific chromosomal sites located near genes contributing to host resistance to infection. The results demonstrate the multigenic nature of susceptibility to urinary tract infections.
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