ArticleOncogene2009
Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters.
Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Relationship Between Human mutL Homolog 1 (hMLH1) Hypermethylation and Colorectal Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2017Pooled it
- Prognostic value of MGMT methylation in colorectal cancer: a meta-analysis and literature review.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features.PloS one · 2013Pooled it
- Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa.Cancer prevention research (Philadelphia, Pa.) · 2010Trial
- Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers.Cancer research and treatment · 2026Article
- IncreasedMolecular & cellular oncology · 2025Article
- Epigenetic differences in the tumor suppressor genesInnovative surgical sciences · 2024Article
- Improved Pathologic response to chemoradiation in MGMT methylated locally advanced rectal cancer.Clinical and translational radiation oncology · 2023Article
- Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences?Updates in surgery · 2022Article
- Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing.Epigenetics · 2022Article
- Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging.Clinical epigenetics · 2020Observational
- DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection.Oncology letters · 2020Article
- Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis.Journal of clinical medicine · 2020Article
- Hypermethylation of the miR-155 gene in the whole blood and decreased plasma level of miR-155 in rheumatoid arthritis.PloS one · 2020Article
- DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.Clinical epigenetics · 2019Article
- Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafCancer cell · 2019Article
- The Developing Story of Predictive Biomarkers in Colorectal Cancer.Journal of personalized medicine · 2019Review
- Article
- Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa.Clinical epigenetics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silencing of gene expression by aberrant cytosine methylation is a prominent feature of human tumors, including colorectal cancers. Epigenetic changes of this type play undisputed roles in cell transformation when they involve genes that safeguard genome stability, and they can also be detected in precancerous lesions and seemingly normal peritumoral tissues. We explored physiological conditions associated with aberrant promoter methylation involving two DNA-repair genes in normal colorectal mucosa. Samples of cecal, transverse colon, sigmoid and rectal mucosa collected from 100 healthy individuals undergoing screening colonoscopy were analysed for hMLH1 and MGMT promoter methylation with a quantitative PCR assay. Positivity in at least one colon segment was common in both sexes, with methylation involving 0.1-18.8% of the alleles (median=0.49%). Samples from males showed no consistent patterns for either promoter, but there were striking age- and colon segment-specific differences in the female subgroup. Here, the prevalence of hMLH1 and MGMT methylation increased significantly with age, particularly in the right colon, where there was also an age-related increase in the percentage of alleles showing hMLH1 methylation. Concomitant methylation of both promoters was also significantly more common in the right colon of women. These findings paralleled immunohistochemical patterns of hMLH1 and MGMT protein loss in an independent series of 231 colorectal cancers and were consistent with current epigenetic profiles of colorectal cancer subsets. They suggest the intriguing possibility that the epigenetic signatures of cancers may have early-stage, normal-tissue counterparts that reflect potentially important aspects of the initial carcinogenetic process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.