ArticleNature genetics2009
Common variants at 30 loci contribute to polygenic dyslipidemia.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 734 papers, 14 of them syntheses that pooled it.
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Who cites it
734 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling.Scientific reports · 2025Pooled it
- Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.European heart journal · 2023Pooled it
- Effect ofCardiovascular therapeutics · 2023Pooled it
- Pooled it
- TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies.Genetics · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals.Arteriosclerosis, thrombosis, and vascular biology · 2022Pooled it
- A Bayesian hierarchically structured prior for gene-based association testing with multiple traits in genome-wide association studies.Genetic epidemiology · 2022Pooled it
- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.Nature communications · 2021Pooled it
- Revisiting the genome-wide significance threshold for common variant GWAS.G3 (Bethesda, Md.) · 2021Pooled it
- Effect of metabolic genetic variants on long-term disease comorbidity in patients with type 2 diabetes.Scientific reports · 2021Pooled it
- Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality.Circulation · 2019Pooled it
- Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation.Nature genetics · 2018Pooled it
- Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke.European heart journal · 2018Pooled it
- Cardiometabolic risk factors are affected by interaction between FADS1 rs174556 variant and dietary vegetable oils in patients with diabetes: a randomized controlled trial.Scientific reports · 2024Trial
- The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets.Molecular nutrition & food research · 2022Trial
- FADS1 (Fatty Acid Desaturase 1) Genotype Associates With Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.Circulation. Genomic and precision medicine · 2020Trial
- Six years' experience with LipidSeq: clinical and research learnings from a hybrid, targeted sequencing panel for dyslipidemias.BMC medical genomics · 2020Trial
- Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?Nutrients · 2019Trial
- Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies.Molecular genetics & genomic medicine · 2019Trial
674 more citing papers are in PubMed but not listed here.
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Funding
Abstract
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.
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