ArticleNature cell biology2009
Apoptotic histone modification inhibits nuclear transport by regulating RCC1.
Article in Nature cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- H3K36me3-Guided mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ran-GTP/-GDP-dependent nuclear accumulation of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and TGACG-BINDING FACTOR2 controls salicylic acid-induced leaf senescence.Plant physiology · 2022Article
- Epigenetic Deregulation of Apoptosis in Cancers.Cancers · 2021Review
- USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.The Journal of experimental medicine · 2020Article
- Tubule-Specific Mst1/2 Deficiency Induces CKDJournal of the American Society of Nephrology : JASN · 2020Article
- Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex.Frontiers in genetics · 2020Article
- The Multifaceted Roles of RCC1 in Tumorigenesis.Frontiers in molecular biosciences · 2020Review
- MiR-101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF-κB signaling.The Kaohsiung journal of medical sciences · 2019Article
- A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export.EMBO reports · 2018Article
- Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way.Cell proliferation · 2018Review
- MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B.The EMBO journal · 2018Article
- Importins α and β signaling mediates endothelial cell inflammation and barrier disruption.Cellular signalling · 2018Article
- Article
- Histone modifications as regulators of life and death inMicrobial cell (Graz, Austria) · 2015Review
- Properties of cells through life and death - an acoustic microscopy investigation.Cell cycle (Georgetown, Tex.) · 2015Article
- Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4.Cancer biology & therapy · 2014Article
- Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin.Biophysical journal · 2013Article
- Mitosis-targeted anti-cancer therapies: where they stand.Cell death & disease · 2012Review
- Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY.Molecular biology of the cell · 2012Article
- The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.Molecular and cellular biology · 2011Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of signalling pathways have been identified that regulate apoptosis, but the mechanism that initiates apoptosis remains incompletely understood. We have found that the nuclear RanGTP level is diminished during the early stages of apoptosis, which correlates with immobilization of RCC1 on the chromosomes. Furthermore, the expression of phosphomimetic histone H2B or caspase-activated Mst1 immobilizes RCC1 and causes reduction of nuclear RanGTP levels, which leads to inactivation of the nuclear transport machinery. As a consequence, nuclear localization signal (NLS)-containing proteins, including NF-kappaB-p65, remain bound to importins alpha and beta in the cytoplasm. Knocking down Mst1 allows resumption of nuclear transport and the nuclear entry of NF-kappaB-p65, which have important roles in rescuing cells from apoptosis. Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.