ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Association between cardiovascular autonomic neuropathy and left ventricular dysfunction: DCCT/EDIC study (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications).Journal of the American College of Cardiology · 2013Trial
- The effect of aerobic training and NBS superfood supplementation on apoptosis and cardiac damage in methamphetamine-withdrawn rats.Scientific reports · 2025Article
- Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology.International journal of molecular sciences · 2024Article
- Insulin-Heart Axis: Bridging Physiology to Insulin Resistance.International journal of molecular sciences · 2024Review
- Can Methamphetamine-Induced Cardiotoxicity be Ameliorated by Aerobic Training and Nutrition Bio-shield Superfood Supplementation in Rats After Withdrawal?Cardiovascular toxicology · 2024Article
- The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms.Frontiers in medicine · 2021Review
- Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options.British journal of pharmacology · 2020Review
- Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events.Frontiers in neuroscience · 2018Review
- Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension.British journal of pharmacology · 2016Article
- Increased serum gamma-glutamyltransferase levels are associated with ventricular instability in type 2 diabetes.Endocrine · 2016Article
- Differential impact of type-1 and type-2 diabetes on control of heart rate in mice.Autonomic neuroscience : basic & clinical · 2016Article
- Cyclooxygenase 2, toll-like receptor 4 and interleukin 1β mRNA expression in atherosclerotic plaques of type 2 diabetic patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Inflammation: therapeutic targets for diabetic neuropathy.Molecular neurobiology · 2014Review
- Modeling and imaging cardiac sympathetic neurodegeneration in Parkinson's disease.American journal of nuclear medicine and molecular imaging · 2014Review
- 12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy.Journal of diabetes mellitus · 2013Article
- Diabetic neuropathy: cellular mechanisms as therapeutic targets.Nature reviews. Neurology · 2011Review
- Autonomic imbalance: prophet of doom or scope for hope?Diabetic medicine : a journal of the British Diabetic Association · 2011Review
- Mechanism of diabetic neuropathy: Where are we now and where to go?Journal of diabetes investigation · 2011Review
- Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.Atherosclerosis · 2010Article
- Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Glucose-mediated oxidative stress and the upregulation of cyclooxygenase (COX)-2 pathway activity have been implicated in the pathogenesis of several vascular complications of diabetes including diabetic neuropathy. However, in nondiabetic subjects, the cardiovascular safety of selective COX-2 inhibition is controversial. The aim of this study was to explore the links between hyperglycemia, oxidative stress, activation of the COX-2 pathway, cardiac sympathetic integrity, and the development of left ventricular (LV) dysfunction in experimental diabetes. R wave-to-R wave interval (R-R interval) and parameters of LV function measured by echocardiography using 1% isoflurane, LV sympathetic nerve fiber density, LV collagen content, and markers of myocardial oxidative stress, inflammation, and PG content were assessed after 6 mo in control and diabetic COX-2-deficient (COX-2(-/-)) and littermate, wild-type (COX-2(+/+)) mice. There were no differences in blood glucose, LV echocardiographic measures, collagen content, sympathetic nerve fiber density, and markers of oxidative stress and inflammation between nondiabetic (ND) COX-2(+/+) and COX-2(-/-) mice at baseline and thereafter. After 6 mo, diabetic COX-2(+/+) mice developed significant deteriorations in the R-R interval and signs of LV dysfunction. These were associated with a loss of LV sympathetic nerve fiber density, increased LV collagen content, and a significant increase in myocardial oxidative stress and inflammation compared with those of ND mice. Diabetic COX-2(-/-) mice were protected against all these biochemical, structural, and functional deficits. These data suggest that in experimental diabetes, selective COX-2 inactivation confers protection against sympathetic denervation and LV dysfunction by reducing intramyocardial oxidative stress, inflammation, and myocardial fibrosis.
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Registered trials
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