ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Cold pressor-induced sympathetic activation blunts the femoral but not carotid artery vascular responsiveness.Physiological reports · 2025Trial
- Impaired modulation of postjunctional αThe Journal of physiology · 2018Trial
- Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults.American journal of physiology. Heart and circulatory physiology · 2015Trial
- Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2015Trial
- Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- The relationship of gender and training experience with post-occlusive hyperemia: experimental comparative study.European journal of applied physiology · 2026Article
- A new sympathetic understanding of exercise blood flow regulation in heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.The Journal of physiology · 2024Article
- Impaired cardiopulmonary baroreflex function and altered cardiovascular responses to hypovolemia in patients with heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Article
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Global REACH 2018: increased adrenergic restraint of blood flow preserves coupling of oxygen delivery and demand during exercise at high-altitude.The Journal of physiology · 2022Article
- Targeting Myocardial Fibrosis-A Magic Pill in Cardiovascular Medicine?Pharmaceutics · 2022Review
- Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications.Antioxidants & redox signaling · 2021Review
- Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- α-Adrenergic receptor regulation of skeletal muscle blood flow during exercise in heart failure patients with reduced ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Vasoconstrictor responsiveness in contracting human muscle: influence of contraction frequency, contractile work, and metabolic rate.European journal of applied physiology · 2017Article
- Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
alpha(1)-Adrenergic vasoconstriction during dynamic leg exercise is diminished in younger individuals, although the extent of this exercise-induced "sympatholysis" in the elderly remains uncertain. Thus, in nine young (25 +/- 1 yr) and six older (72 +/- 2 yr) healthy volunteers, we evaluated changes in leg blood flow (ultrasound Doppler) during blood flow-adjusted intra-arterial infusion of phenylephrine (PE; a selective alpha(1)-adrenergic agonist) at rest and during knee-extensor leg exercise at 20, 40, and 60% of maximal work rate (WR(max)). To probe the potential contributors to exercise-induced changes in alpha(1)-adrenergic receptor sensitivity, exercising leg O(2) consumption (Vo(2)) and lactate efflux were also evaluated (n = 10). At rest, the PE-induced vasoconstriction (i.e., decrease in leg blood flow) was diminished in older (-37 +/- 3%) compared with young (-54 +/- 4%) subjects. During exercise, the magnitude of alpha(1)-adrenergic vasoconstriction in the active leg decreased in both groups. However, compared with young, older subjects maintained a greater vasoconstrictor response to PE at 40% WR(max) (-14 +/- 3%, older; -7 +/- 2%, young) and 60% WR(max) (-11 +/- 3%, older; -4 +/- 3%, young). It is possible that this observation may be attributed to lower absolute work rates in the older group, because, for a similar absolute work rate ( approximately 10 W) and leg Vo(2) ( approximately 0.36 l/min), vasoconstriction to PE was not different between groups (-14 +/- 3%; older; -17 +/- 5%, young). Together, these data challenge the concept of reduced sympatholysis in the elderly, suggesting instead that the inhibition of alpha(1)-adrenergic vasoconstriction in the exercising leg is associated with work performed and, therefore, more closely related to the rate of oxidative metabolism than to age per se.
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Registered trials
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