ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- CRHR2 (Corticotropin-Releasing Hormone Receptor 2) in the Nucleus of the Solitary Tract Contributes to Intermittent Hypoxia-Induced Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats.Scientific reports · 2016Article
- Protective effect of histamine microinjected into the cerebellar fastigial nucleus on stress-induced gastric mucosal damage in rats.American journal of translational research · 2015Article
- Mechanisms of cardiovascular actions of urocortins in the hypothalamic arcuate nucleus of the rat.American journal of physiology. Heart and circulatory physiology · 2013Article
- Muscimol microinjection into cerebellar fastigial nucleus exacerbates stress-induced gastric mucosal damage in rats.Acta pharmacologica Sinica · 2013Article
- Bradycardic effects of microinjections of urocortin 3 into the nucleus ambiguus of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- The hypothalamic arcuate nucleus: a new site of cardiovascular action of angiotensin-(1-12) and angiotensin II.American journal of physiology. Heart and circulatory physiology · 2011Article
- Cardiovascular responses elicited by a new endogenous angiotensin in the nucleus tractus solitarius of the rat.American journal of physiology. Heart and circulatory physiology · 2011Article
- Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia.American journal of physiology. Heart and circulatory physiology · 2011Article
- Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.American journal of physiology. Heart and circulatory physiology · 2009Article
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3 authors at 1 institution in 1 country.
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Abstract
Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence of CRF(2)Rs has been reported in the nucleus tractus solitarius (NTS) of the rat. It was hypothesized that the activation of CRF2Rs in the medial NTS (mNTS) may play a role in cardiovascular regulation. This hypothesis was tested in urethane-anesthetized, artificially ventilated, adult male Wistar rats. Microinjections (100 nl) of Ucn3 (0.03, 0.06, 0.12, and 0.25 mM) into the mNTS of anesthetized rats elicited decreases in mean arterial pressure (MAP: 5.0 +/- 1.0, 21.6 +/- 2.6, 20.0 +/- 2.8, and 12.7 +/- 3.4 mmHg, respectively) and heart rate (HR: 7.8 +/- 2.6, 46.2 +/- 9.3, 34.5 +/- 8.4, and 16.6 +/- 4.9 beats/min, respectively). Microinjections of artificial cerebrospinal fluid (100 nl) into the mNTS did not elicit cardiovascular responses. Maximum decreases in MAP and HR were elicited by 0.06 mM concentration of Ucn3. Cardiovascular responses to Ucn3 were similar in unanesthetized midcollicular decerebrate rats. A bilateral vagotomy completely abolished Ucn3-induced bradycardia. The decreases in MAP and HR elicited by Ucn3 (0.06 mM) were completely blocked by astressin (1 mM; nonselective CRFR antagonist) and K41498 (5 mM; selective CRF2R antagonist). Microinjections of Ucn3 (0.06 mM) into the mNTS decreased the efferent greater splanchnic nerve activity. After the blockade of CRF2Rs in the mNTS, a Ucn3-induced decrease in the efferent sympathetic nerve discharge was abolished. These results indicate that Ucn3 microinjections into the mNTS exerted excitatory effects on the mNTS neurons via CRF2Rs, leading to depressor and bradycardic responses.
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