ArticleAmerican journal of respiratory cell and molecular biology2009
NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans.
Article in American journal of respiratory cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Association Between Air Pollution and Lung Lobar Emphysema in COPD.Frontiers in medicine · 2021Article
- Erratum: NAD(P)H Quinone Oxidoreductase 1 Is Essential for Ozone-Induced Oxidative Stress in Mice and Humans.American journal of respiratory cell and molecular biology · 2016Article
- Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach.Environmental health perspectives · 2014Review
- Oxidative Stress and Therapeutic Development in Lung Diseases.Journal of pulmonary & respiratory medicine · 2014Article
- Regulation of Wnt4 in chronic obstructive pulmonary disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Increased expression of senescence markers in cystic fibrosis airways.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation.The Journal of biological chemistry · 2013Article
- Genes of innate immunity and the biological response to inhaled ozone.Journal of biochemical and molecular toxicology · 2013Review
- NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Biochemical effects of ozone on asthma during postnatal development.Biochimica et biophysica acta · 2011Review
- Isoprostanes and asthma.Biochimica et biophysica acta · 2011Review
- PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Ambient ozone and pulmonary innate immunity.Immunologic research · 2011Review
- Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.Cell metabolism · 2010Article
- Update in environmental and occupational medicine 2009.American journal of respiratory and critical care medicine · 2010Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1). We hypothesized that after ozone exposure, NQO1 is required to increase 8-isoprostane (also known as F(2)-isoprostane) production, a recognized marker of ozone-induced oxidative stress, and to enhance airway inflammation and hyperresponsiveness. In this report, we demonstrate that in contrast to wild-type mice, NQO1-null mice are resistant to ozone and have blunted responses, including decreased production of F(2)-isoprostane and keratinocyte chemokine, decreased airway inflammation, and diminished airway hyperresponsiveness. Importantly, these results in mice correlate with in vitro findings in humans. In primary human airway epithelial cells, inhibition of NQO1 by dicumarol blocks ozone-induced F(2)-isoprostane production and IL-8 gene expression. Together, these results demonstrate that NQO1 modulates cellular redox status and influences the biologic and physiologic effects of ozone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.