ArticleBlood2009
Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Atypical and non-classical CD45RBNature communications · 2024Article
- Tissue-specific sex differences in pediatric and adult immune cell composition and function.Frontiers in immunology · 2024Article
- A synthetic human 3DiScience · 2023Article
- CD45RB Glycosylation and Ig Isotype Define Maturation of Functionally Distinct B Cell Subsets in Human Peripheral Blood.Frontiers in immunology · 2022Article
- Article
- Article
- Glycosylation in health and disease.Nature reviews. Nephrology · 2019Review
- Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments.Nature communications · 2019Article
- Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.Frontiers in immunology · 2019Review
- Chronic airway inflammation provides a unique environment for B cell activation and antibody production.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination.PloS one · 2017Article
- The myeloma stem cell concept, revisited: from phenomenology to operational terms.Haematologica · 2016Review
- Gut-Homing Conventional Plasmablasts and CD27(-) Plasmablasts Elicited after a Short Time of Exposure to an Oral Live-Attenuated Shigella Vaccine Candidate in Humans.Frontiers in immunology · 2014Article
- TGFβ activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells.PloS one · 2014Article
- KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation.The Journal of clinical investigation · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We previously reported that RO(+) expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we subdivided human tonsillar B cells, including IgD(-)CD38(+) GC B cells, into different fractions based on RB expression. Although each subset contained RB(+) cells, when used as an intrasubset marker, differential RB expression effectively discriminated between phenotypically distinct cells. For example, RB(+) GC B cells were enriched for activated cells with lower AID expression. RB inversely correlated with mutation frequency, demonstrating a key difference between RB- and RO-expressing GC B cells. Reduced RB expression during the transition from pre-GC (IgM(+)IgD(+)CD38(+)CD27(-)) to GCB cells was followed by a dramatic increase during the GC-to-plasmablast (IgD(-)CD38(++)CD27(+)) and memory (IgD(-)CD38(-)CD27(+)) transition. Interestingly, RB(+) GC B cells showed increased signs of terminal differentiation toward CD27(+) post-GC early plasmablast (increased CD38 and RO) or early memory (decreased CD38 and RO) B cells. We propose that as in T cells, differential RB expression directly correlates with development- and function-based transitions in tonsillar B cells. Application of this RB:RO system should advance our understanding of normal B-cell development and facilitate the isolation of more discrete B-cell populations with potentially different propensities in disease pathogenesis.
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Registered trials
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