ArticleMolecular and cellular neurosciences2009
Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 36 citations in OpenAlex.
- Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration.PLoS genetics · 2025Article
- Distinct Bin/Amphiphysin/Rvs (BAR) family proteins may assemble on the same tubule to regulate membrane organizationHeliyon · 2024Article
- PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022Review
- RNAi Screen inG3 (Bethesda, Md.) · 2019Article
- Synaptic Vesicle Endocytosis in Different Model Systems.Frontiers in cellular neuroscience · 2018Review
- Filamin, a synaptic organizer ineLife · 2016Article
- The influence of postsynaptic structure on missing quanta at the Drosophila neuromuscular junction.BMC neuroscience · 2016Article
- Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo.Molecular biology of the cell · 2016Article
- Article
- An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function.Molecular biology of the cell · 2015Article
- Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila.G3 (Bethesda, Md.) · 2012Article
- Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I.The EMBO journal · 2011Article
- Let's go bananas: revisiting the endocytic BAR code.The EMBO journal · 2011Review
- The F-BAR protein family Actin' on the membrane.Communicative & integrative biology · 2010Article
- Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development.PloS one · 2009Article
- F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Syndapin promotes formation of a postsynaptic membrane system in Drosophila.Molecular biology of the cell · 2009Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
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Abstract
Syndapin is a conserved dynamin-binding protein, with predicted function in synaptic-vesicle endocytosis. Here, we combine genetic mutational analysis with in vivo cell biological assays to ask whether Drosophila syndapin (Synd) is an essential component of synaptic-vesicle recycling. The only isoform of Drosophila syndapin (synd) is broadly expressed and at high levels in the nervous system. synd mutants are late-larval lethals, but fertile adult "escapers" frequently emerge. Contrary to expectation, we report that the Synd protein is predominantly postsynaptic, undetectable at presynaptic varicosities at Drosophila third-instar larval neuromuscular junctions. Electrophysiological and synaptopHluorin imaging in control, synd-deficient or synd-overexpressing motor neurons reveals that synd is dispensable for synaptic-vesicle endocytosis. Our work in Drosophila leads to the suggestion that syndapin may not be a general or essential component in dynamin-dependent synaptic-vesicle endocytosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.