ArticleDevelopmental biology2009
Temporal regulation of Ath5 gene expression during eye development.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.Human molecular genetics · 2010Pooled it
- Genetic analysis of medaka fish illuminates conserved and divergent roles of Pax6 in vertebrate eye development.Frontiers in cell and developmental biology · 2024Article
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Building a Mammalian Retina: An Eye on Chromatin Structure.Frontiers in genetics · 2021Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis.Frontiers in cell and developmental biology · 2020Article
- Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.Scientific reports · 2018Article
- All in the family: proneural bHLH genes and neuronal diversity.Development (Cambridge, England) · 2018Review
- Retinoid acid and taurine promote NeuroD1-induced differentiation of induced pluripotent stem cells into retinal ganglion cells.Molecular and cellular biochemistry · 2018Article
- Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.Development (Cambridge, England) · 2014Article
- The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development.Mechanisms of development · 2014Article
- Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.Developmental biology · 2014Article
- Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.PloS one · 2012Article
- Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease.Nature neuroscience · 2011Article
- Development of the retina and optic pathway.Vision research · 2011Review
- Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate.Vision research · 2011Article
- Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.Developmental biology · 2011Article
- Neurog2 controls the leading edge of neurogenesis in the mammalian retina.Developmental biology · 2010Article
- Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A global survey identifies novel upstream components of the Ath5 neurogenic network.Genome biology · 2009Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
During central nervous system development the timing of progenitor differentiation must be precisely controlled to generate the proper number and complement of neuronal cell types. Proneural basic helix-loop-helix (bHLH) transcription factors play a central role in regulating neurogenesis, and thus the timing of their expression must be regulated to ensure that they act at the appropriate developmental time. In the developing retina, the expression of the bHLH factor Ath5 is controlled by multiple signals in early retinal progenitors, although less is known about how these signals are coordinated to ensure correct spatial and temporal pattern of gene expression. Here we identify a key distal Xath5 enhancer and show that this enhancer regulates the early phase of Xath5 expression, while the proximal enhancer we previously identified acts later. The distal enhancer responds to Pax6, a key patterning factor in the optic vesicle, while FGF signaling regulates Xath5 expression through sequences outside of this region. In addition, we have identified an inhibitory element adjacent to the conserved distal enhancer region that is required to prevent premature initiation of expression in the retina. This temporal regulation of Xath5 gene expression is comparable to proneural gene regulation in Drosophila, whereby separate enhancers regulate different temporal phases of expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.