ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2008
CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A meta-analysis of chemokines in vitiligo: Recruiting immune cells towards melanocytes.Frontiers in immunology · 2023Pooled it
- CXCL12 is a potential therapeutic target for type 2 diabetes mellitus complicated by chronic obstructive pulmonary disease.Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Cutaneous Exposure to Arsenicals Is Associated with Development of Constrictive Bronchiolitis in Mice.American journal of respiratory cell and molecular biology · 2023Article
- Regulation of T Cells in Cancer by Nitric Oxide.Cells · 2021Review
- Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.Scientific reports · 2018Article
- Article
- Immune-mediated vascular injury and dysfunction in transplant arteriosclerosis.Frontiers in immunology · 2014Review
- Bluetongue virus - 23 stimulates inducible nitric oxide synthase expression and nitric oxide production in mononuclear cells of blood and/or regional lymphoid organs.Veterinary research communications · 2012Article
- Participation of blood vessel cells in human adaptive immune responses.Trends in immunology · 2012Review
- Generation of NO by bystander human CD8 T cells augments allogeneic responses by inhibiting cytokine deprivation-induced cell death.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe reported previously that inducible nitric oxide synthase (iNOS) expression in graft-infiltrating human T cells that is confined to the bystander population contributes to T- cell-mediated rejection of allograft arteries in a humanized mouse model. Herein we examine whether CXCL12, a chemokine thought to contribute to recruitment of bystander T cells, induces iNOS in human CD8 T cells.
methodsHuman CD8 T cells were treated with CXCL12 and iNOS expression was examined. Also, human allograft arteries were immunohistochemically stained for iNOS and CD8, and adjacent sections stained for CXCL12 to determine their localization in human tissues.
resultsResting human CD8 and CD4 T cells expressed the CXCR4, but not the CXCR7, receptor for CXCL12. Treatment with CXCL12 induced expression of both iNOS mRNA and protein in primary human CD8 T cells in a dose-dependent manner, but had no effect on CD4 T cells. Induction of iNOS expression in CD8 T cells was mediated by increased gene transcription. T-cell-receptor (TCR)-activated CD8 T cells rapidly downregulated CXCR4, which coincided with diminished ability of CXCL12 to induce iNOS in activated T cells. iNOS expression in infiltrating human CD8 T cells was spatially associated with CXCL12 expression both in the humanized mouse model of allograft artery rejection and in clinical specimens of coronary arteries displaying allograft vasculopathy.
conclusionsCXCL12 induces iNOS expression in human CD8 T cells and this response may contribute to allograft rejection.
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