ArticleTrends in immunology2009
Virus-specific host miRNAs: antiviral defenses or promoters of persistent infection?
Article in Trends in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- The impact of host microRNAs on the development of conserved mutations of SARS-CoV-2.Scientific reports · 2024Article
- The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression.Journal of cell science · 2023Article
- The Influence of Host miRNA Binding to RNA Within RNA Viruses on Virus Multiplication.Frontiers in cellular and infection microbiology · 2022Review
- Implications of SARS-CoV-2 Mutations for Genomic RNA Structure and Host microRNA Targeting.International journal of molecular sciences · 2020Article
- An HBV-encoded miRNA activates innate immunity to restrict HBV replication.Journal of molecular cell biology · 2020Article
- Review
- Extracellular RNA in viral-host interactions: Thinking outside the cell.Wiley interdisciplinary reviews. RNA · 2019Review
- Aedes aegypti microRNA, miR-2944b-5p interacts with 3'UTR of chikungunya virus and cellular target vps-13 to regulate viral replication.PLoS neglected tropical diseases · 2019Article
- Measles Virus Persistent Infection of Human Induced Pluripotent Stem Cells.Cellular reprogramming · 2018Article
- MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5.Journal of virology · 2018Article
- Shrimp miR-1000 Functions in Antiviral Immunity by Simultaneously Triggering the Degradation of Two Viral mRNAs.Frontiers in immunology · 2018Article
- Article
- Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes.BMC genomics · 2016Article
- A Tale of Two RNAs during Viral Infection: How Viruses Antagonize mRNAs and Small Non-Coding RNAs in The Host Cell.Viruses · 2016Review
- Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.Viruses · 2016Article
- Virus tolerance and recovery from viral induced-symptoms in plants are associated with transcriptome reprograming.Plant molecular biology · 2015Review
- Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes.Protein & cell · 2015Article
- An ensemble approach to the evolution of complex systems.Journal of biosciences · 2014Review
- Plant miRNAome and antiviral resistance: a retrospective view and prospective challenges.Virus genes · 2014Review
- Identification and analysis of differential miRNAs in PK-15 cells after foot-and-mouth disease virus infection.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The discovery of host-microRNA (miRNA) targets in the genomes of many vertebrate viruses indicates that the corresponding miRNAs are a part of the host's innate antiviral defense. However, given that viruses evolve much faster than host miRNAs, it is surprising that viral variants lacking these 'antiviral' miRNA target sequences have not become established. We present an alternate view that miRNAs are among the host molecules that viruses co-opt to suppress their own replication to evade immune elimination and establish a persistent infection. The presence of host-miRNA targets in the genomes of rapidly evolving viruses probably reflects the adaptation of these viruses to the cellular miRNA milieu.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.