ArticleJournal of feline medicine and surgery2009
Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen.
Article in Journal of feline medicine and surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 56 citations in OpenAlex.
- High-Sensitive Cardiac Troponin I and Th1/Th2 Polarization in Queens With Pyometra.Veterinary medicine and science · 2025Article
- Evaluation of the efficacy and safety of toceranib phosphate in cats with macroscopic mammary adenocarcinoma.Journal of feline medicine and surgery · 2024Article
- Feline breeding and pregnancy management: What is normal and when to intervene.Journal of feline medicine and surgery · 2022Review
- Contraceptive implants used by cat breeders in France: a study of 140 purebred cats.Journal of feline medicine and surgery · 2020Article
- Effect of melatonin on the reproductive cycle in female cats: a review of clinical experiences and previous studies.Journal of feline medicine and surgery · 2017Review
- Progestins to control feline reproduction: Historical abuse of high doses and potentially safe use of low doses.Journal of feline medicine and surgery · 2015Review
- Mammary tumours in the cat: size matters, so early intervention saves lives.Journal of feline medicine and surgery · 2013Review
- Semi-Ownership and Sterilisation of Cats and Dogs in Thailand.Animals : an open access journal from MDPI · 2012Article
- Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Progesterone intoxication inducing marked sedation in a cat.Journal of feline medicine and surgery · 2010Article
- Reproduction control - new developments, old debates.Journal of feline medicine and surgery · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH-P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH-P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.