ArticleMaturitas2009
A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females.
Article in Maturitas, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link?Frontiers in genetics · 2026Article
- Role of estrogen in women's Alzheimer's disease risk as modified by APOE.Journal of neuroendocrinology · 2023Review
- Apolipoprotein E and Alzheimer's disease.Acta pharmaceutica Sinica. B · 2022Review
- Women's reproductive span: a systematic scoping review.Human reproduction open · 2022Article
- Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.Frontiers in genetics · 2020Article
- Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women.European journal of epidemiology · 2019Article
- Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.Lipids in health and disease · 2015Article
- Genomic markers of ovarian reserve.Seminars in reproductive medicine · 2013Review
- Article
- ApoE genotypes are associated with age at natural menopause in Chinese females.Age (Dordrecht, Netherlands) · 2012Article
- Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2012Review
- SNP-SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis.Rheumatology international · 2011Article
- APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population.Lipids in health and disease · 2010Article
- ALOX12 gene is associated with the onset of natural menopause in white women.Menopause (New York, N.Y.)Article
- TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women.Menopause (New York, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females.
designFour SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted.
resultsAlcohol consumption was a significantly predictor of earlier natural menopause (P<0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P=0.007 and 0.046, respectively). However, no association was observed between APOE varepsilon2, varepsilon3, varepsilon4 and ANM.
conclusionsGenetic variation in the APOE gene may influence the variation in ANM in Caucasian women.
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Registered trials
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