ReviewWorld journal of gastroenterology2008
Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements.
Review in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements usingFEBS open bio · 2026Article
- Hepatotoxicity of dietary supplements containingPharmaceutical biology · 2025Review
- Toxicity Potential of Nutraceuticals.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Epidemiology of Newly Recognized Causes of Drug-Induced Liver Injury: An Update.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Physiological and pathological roles of lipogenesis.Nature metabolism · 2023Review
- Clinical and Forensic Signs Resulting from Exposure to Heavy Metals and Other Chemical Elements of the Periodic Table.Journal of clinical medicine · 2023Review
- Article
- Herb-drug Interactions in Neuropsychiatric Pharmacotherapy - A Review of Clinically Relevant Findings.Current neuropharmacology · 2022Review
- HLA-B*35:01 and Green Tea-Induced Liver Injury.Hepatology (Baltimore, Md.) · 2021Article
- Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight.Nutrients · 2021Review
- Article
- Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs.World journal of hepatology · 2020Review
- Article
- United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts.Toxicology reports · 2020Review
- Hepatotoxicity associated withWorld journal of hepatology · 2019Article
- Hydroxycitrate: a potential new therapy for calcium urolithiasis.Urolithiasis · 2019Review
- Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Review
- Acute liver injury following Garcinia cambogia weight-loss supplementation: case series and literature review.Internal and emergency medicine · 2018Review
- Is obesity rather than the dietary supplement used for weight reduction the cause of liver injury?JGH open : an open access journal of gastroenterology and hepatology · 2018Review
- Asystole caused by Hydroxycut Hardcore: A case report and literature review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demonstrated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.