ArticleWorld journal of gastroenterology2008
Prevalence of celiac disease in adult patients with refractory functional dyspepsia: value of routine duodenal biopsy.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02820064 (Effects of Hypoxia and Inflammation on Citrulline Synthesis by Ornithine Transcarbamylase in Human Enterocytes), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Hypoxia and Inflammation on Citrulline Synthesis by Ornithine Transcarbamylase in Human Enterocytes
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- The genetic association between celiac disease and risk of functional dyspepsia: A Mendelian randomization study.Medicine · 2026Article
- Non-Diarrheal Celiac Disease in Iraq: A Multicenter study.Middle East journal of digestive diseases · 2025Article
- Article
- Seronegative Celiac Disease in Patients with Isolated Refractory Dyspepsia and Gastroesophageal Reflux Disease.Gut and liver · 2022Article
- Routine Multiple Duodenal Biopsy during Endoscopy of Dyspeptic Patients Seems Unnecessary for Screening of Celiac Disease.Gastroenterology research and practice · 2020Article
- Low Yield and High Cost of Gastric and Duodenal Biopsies for Investigation of Symptoms of Abdominal Pain During Routine Esophagogastroduodenoscopy.Digestive diseases and sciences · 2017Article
- Cost Effectiveness of Routine Duodenal Biopsy Analysis for Celiac Disease During Endoscopy for Gastroesophageal Reflux.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Low yield of routine duodenal biopsies for evaluation of abdominal pain.World journal of gastroenterology · 2015Article
- Psychological morbidity of celiac disease: A review of the literature.United European gastroenterology journal · 2015Review
- Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy.World journal of methodology · 2014Review
- Prior endoscopy in patients with newly diagnosed celiac disease: a missed opportunity?Digestive diseases and sciences · 2013Article
- Frequency of celiac disease in adult patients with typical or atypical malabsorption symptoms in isfahan, iran.Gastroenterology research and practice · 2012Article
- Gluten associated dyspepsia; serology and histological characteristics.Gastroenterology and hepatology from bed to bench · 2012Article
- Gluten and dyspepsia.Gastroenterology and hepatology from bed to bench · 2012Article
- Evaluation and management of dyspepsia.Therapeutic advances in gastroenterology · 2010Article
- Celiac disease in patients with presumed irritable bowel syndrome: a case-finding study.World journal of gastroenterology · 2009Article
- Celiac disease is increased in esophageal squamous cell Carcinoma.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gastroenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia.
methodsSeven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duodenal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber criteria.
resultsThe endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.
conclusionThis prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.
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