ArticleWorld journal of gastroenterology2008
Helicobacter pylori damages human gallbladder epithelial cells in vitro.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Effects and mechanisms ofWorld journal of gastroenterology · 2024Review
- Decipher the Helicobacter pylori Protein Targeting in the Nucleus of Host Cell and their Implications in Gallbladder Cancer: AnJournal of Cancer · 2021Article
- Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.Bioinformation · 2019Article
- Helicobacter species and common gut bacterial DNA in gallbladder with cholecystitis.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the mechanism by which Helicobacter pylori (H pylori) damages human gallbladder epithelial cells (HGBEC).
methodsH pylori isolated from gallbladder were cultured in a liquid medium. Different concentration supernatants and sonicated extracts of H pylori cells were then added to HGBEC in a primary culture. The morphological changes in HGBEC as well as changes in the levels of alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and glutamyltransferase (GGT) were measured.
resultsAccording to the culture curve of HGBEC, it was convenient to study the changes in HGBEC by adding H pylori sonicated extracts and H pylori culture supernatants. Both H pylori sonicated extracts and H pylori culture supernatants had a significant influence on HGBEC morphology, i.e. HGBEC grew more slowly, their viability decreased and their detachment increased. Furthermore, HGBEC ruptured and died. The levels of ALP (33.84+/-6.00 vs 27.01+/-4.67, P<0.05), LDH (168.37+/-20.84 vs 55.51+/-17.17, P<0.01) and GGT (42.01+/-6.18 vs 25.34+/-4.33, P<0.01) significantly increased in the HGBEC culture supernatant in a time- and concentration-dependent. The damage to HGBEC in H pylori culture liquid was more significant than that in H pylori sonicated extracts.
conclusionH pylori induces no obvious damage to HGBEC.
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Registered trials
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