ArticleWorld journal of gastroenterology2008
Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- The Renin-Angiotensin System in Liver Disease.International journal of molecular sciences · 2024Review
- Isolated Subclinical Right Ventricle Systolic Dysfunction in Patients after Liver Transplantation.Journal of clinical medicine · 2023Article
- Association of COVID-19 with Comorbidities: An Update.ACS pharmacology & translational science · 2023Review
- COVID and the Renin-Angiotensin System: Are Hypertension or Its Treatments Deleterious?Frontiers in cardiovascular medicine · 2020Article
- Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation.Journal of clinical medicine · 2019Article
- Renin angiotensin system in liver diseases: Friend or foe?World journal of gastroenterology · 2017Review
- Hemodynamic effects of renin-angiotensin-aldosterone inhibitor and β-blocker combination therapy vs. β-blocker monotherapy for portal hypertension in cirrhosis: A meta-analysis.Experimental and therapeutic medicine · 2017Article
- β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis.World journal of gastroenterology · 2015Article
- Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms.American journal of Alzheimer's disease and other dementias · 2013Review
- The role of β-adrenergic blockers in Parkinson's disease: possible genetic and cell-signaling mechanisms.American journal of Alzheimer's disease and other dementias · 2013Review
- The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms.Cancer management and research · 2012Article
- Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Terlipressin and hepatorenal syndrome: what is important for nephrologists and hepatologists.World journal of gastroenterology · 2010Review
- Relationship between angiotensin-(1-7) and angiotensin II correlates with hemodynamic changes in human liver cirrhosis.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effect of beta-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not.
methodsPatients were allocated into two groups: outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA), Angiotensin(Ang) I, Ang II, and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation, hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.
resultsPRA, Ang I, Ang II and Ang-(1-7) were significantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang I levels and between Ang II and Ang I were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang II remained unchanged in splanchnic and peripheral circulation in patients under beta-blockade, whereas the relationship between Ang II and Ang I was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation, cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup.
conclusionIn LD group, propranolol treatment reduced RAS mediators, but did not change the ratio between Ang-(1-7) and Ang II in splanchnic and peripheral circulation. Furthermore, the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio.
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