ArticleGenetic epidemiology2009
Allelic-based gene-gene interaction associated with quantitative traits.
Article in Genetic epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Aggregation of experts: an application in the field of "interactomics" (detection of interactions on the basis of genomic data).BMC bioinformatics · 2018Article
- Cuckoo search epistasis: a new method for exploring significant genetic interactions.Heredity · 2014Article
- Novel likelihood ratio tests for screening gene-gene and gene-environment interactions with unbalanced repeated-measures data.Genetic epidemiology · 2013Article
- Principal interactions analysis for repeated measures data: application to gene-gene and gene-environment interactions.Statistics in medicine · 2012Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Physiology and pathophysiology of the calcium-sensing receptor in the kidney.American journal of physiology. Renal physiology · 2010Review
- Allelic based gene-gene interaction in case-control studies.Human heredity · 2010Article
- Allelic based gene-gene interactions in rheumatoid arthritis.BMC proceedings · 2009Article
- Individualized pain medicine.Drug discovery today. Therapeutic strategies · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent studies have shown that quantitative phenotypes may be influenced not only by multiple single nucleotide polymorphisms (SNPs) within a gene but also by the interaction between SNPs at unlinked genes. We propose a new statistical approach that can detect gene-gene interactions at the allelic level which contribute to the phenotypic variation in a quantitative trait. By testing for the association of allelic combinations at multiple unlinked loci with a quantitative trait, we can detect the SNP allelic interaction whether or not it can be detected as a main effect. Our proposed method assigns a score to unrelated subjects according to their allelic combination inferred from observed genotypes at two or more unlinked SNPs, and then tests for the association of the allelic score with a quantitative trait. To investigate the statistical properties of the proposed method, we performed a simulation study to estimate type I error rates and power and demonstrated that this allelic approach achieves greater power than the more commonly used genotypic approach to test for gene-gene interaction. As an example, the proposed method was applied to data obtained as part of a candidate gene study of sodium retention by the kidney. We found that this method detects an interaction between the calcium-sensing receptor gene (CaSR), the chloride channel gene (CLCNKB) and the Na, K, 2Cl cotransporter gene (CLC12A1) that contributes to variation in diastolic blood pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.