ArticleDigestive diseases and sciences2009
Synaptic plasticity: the new explanation of visceral hypersensitivity in rats with Trichinella spiralis infection?
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.Gastroenterology · 2019Guideline
- Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome.Journal of gastroenterology · 2011Pooled it
- Electrophysiology as a Tool to Decipher the Network Mechanism of Visceral Pain in Functional Gastrointestinal Disorders.Diagnostics (Basel, Switzerland) · 2023Review
- How Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats.Drug design, development and therapy · 2023Article
- Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome.Neurogastroenterology and motility · 2022Review
- Maintenance of Intestinal Homeostasis in Diarrhea-Predominant Irritable Bowel Syndrome by Electroacupuncture Through Submucosal Enteric Glial Cell-Derived S-Nitrosoglutathione.Frontiers in physiology · 2022Article
- Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis.International journal of molecular sciences · 2019Review
- Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients.World journal of gastroenterology · 2016Article
- Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside.Journal of neurogastroenterology and motility · 2016Review
- Mast Cell-dependent Mesenteric Afferent Activation by Mucosal Supernatant From Different Bowel Segments of Guinea Pigs With Post-infectious Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSynaptic plasticity plays an important role in affecting the intensity of visceral reflex. It may also be involved in the development of visceral hypersensitivity. The aim of this study was to investigate the role of synaptic plasticity on visceral hypersensitivity of rats infected by Trichinella spiralis.
methodsThirty male Sprague-Dawley (SD) rats were randomly divided into control, acute, and chronic infection groups, and were investigated at 1 week after adaptive feeding and at 2 and 8 weeks post infection (PI) by oral administration of 1 ml phosphate-buffered saline (PBS) containing 8,000 Trichinella spiralis larvae. Visceral sensitivity was evaluated by electromyography (EMG) recording during colorectal distension. Intestinal inflammation was observed by hematoxylin-eosin (HE) staining. Synaptic ultrastructure parameters, such as postsynaptic density (PSD) length, synaptic cleft, and number of synaptic vesicles, were examined by transmission electron microscopy (TEM). The expression of protein associated with synaptic plasticity, including postsynaptic density-95 (PSD-95), synaptophysin, calbindin-28 K, N-methyl-D-aspartate receptor-1 (NMDA-R1), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPA-R), and glial cell line-derived neurotrophic factor (GDNF), were analyzed by Western blot.
results(1) Visceral hypersensitivity was noted in the chronic infection group, although the inflammation was nearly eliminated (P<0.05). Severe inflammation and downregulation of visceral sensitivity were observed in the acute infection group (P<0.05). (2) There were many more synaptic vesicles and longer PSD in the chronic infection group than in the control group (P<0.05, respectively). However, in comparison with control rats, disappearance of mitochondria cristae in the synapses, and decrease of synaptic vesicles and length of PSD were observed in the acute infection group. There was no significant difference in width of synaptic cleft among the three groups. (3) Compared with the control, the expression of proteins associated with synaptic plasticity was significantly upregulated during chronic infection phase (P<0.05), and downregulated during acute infection phase.
conclusionSynaptic plasticity was observed in SD rats infected by Trichinella spiralis and was associated with visceral sensitivity, which suggests that it may play an important role in the formation of visceral hypersensitivity.
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