Evidence map›Paper›PMID 19057990›Full record

ArticleJournal of assisted reproduction and genetics2009

Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey.

Sevki Cetinkalp, Muammer Karadeniz, Mehmet Erdogan, Ayhan Zengi, Vildan Cetintas, Asli Tetik, Zuhal Eroglu, Buket Kosova, A Gokhan Ozgen, Fusun Saygili and 1 more

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Metformin for endometrial hyperplasia.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sevki CetinkalpDepartment of Endocrinology and Metabolism Disease, Division of Internal Medicine, Ege University Hospital, Izmir, Turkey.
Muammer Karadeniz
Mehmet Erdogan
Ayhan Zengi
Vildan Cetintas
Asli Tetik
Zuhal Eroglu
Buket Kosova
A Gokhan Ozgen
Fusun Saygili
Candeger Yilmaz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects.

methodsIn this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis.

resultsThe Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS.

conclusionsAlthough there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.

Indexed as

Polymorphism, GeneticAdultApolipoproteins ECardiovascular DiseasesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansLuteinizing HormonePolycystic Ovary SyndromeProlactinRisk FactorsSequence Analysis, DNATurkeyApolipoproteins ELuteinizing HormoneProlactin

Identifiers

PMID19057990
PMCPMC2649336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.