ArticleEnvironmental health perspectives2008
Associations of serum concentrations of persistent organic pollutants with the prevalence of periodontal disease and subpopulations of white blood cells.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- A systematic evidence map for the evaluation of noncancer health effects and exposures to polychlorinated biphenyl mixtures.Environmental research · 2023Pooled it
- A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations.Journal of racial and ethnic health disparities · 2020Pooled it
- Association of per- and polyfluoroalkyl substances (PFAS) with periodontitis: the mediating role of sex hormones.BMC oral health · 2024Article
- Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review.International journal of environmental research and public health · 2022Review
- Children's white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Exposure to lipophilic chemicals as a cause of neurological impairments, neurodevelopmental disorders and neurodegenerative diseases.Interdisciplinary toxicology · 2013Review
- Lipophilic chemical exposure as a cause of cardiovascular disease.Interdisciplinary toxicology · 2013Review
- Epidemiologic patterns of chronic and aggressive periodontitis.Periodontology 2000 · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent organic pollutants (POPs), which are endocrine disruptors that accumulate in adipose tissue, can increase the risk of periodontal disease through the disturbance of the immune system.
objectiveWe examined associations of background exposure to POPs with periodontal disease in the general population.
designCross-sectional associations of concentrations of serum POPs with the prevalence of periodontal disease were investigated in 1,234 adults > or = 20 years of age in the National Health and Nutrition Examination Survey 1999-2002.
resultsAmong several POPs, organochlorine (OC) pesticides were most strongly associated with periodontal disease. Adjusted odds ratios across quintiles of OC pesticides were 1.0, 1.3, 1.7, 2.4, and 2.7 (p for trend < 0.01) for the presence in any site of clinical attachment loss > or = 4 mm and 1.0, 1.7, 2.6, 3.4, and 3.7 (p for trend < 0.01) for the presence of pocket depth > or = 4 mm. Polychlorinated biphenyls and polychlorinated dibenzo-p-dioxins also showed significant positive associations with one or both definitions of periodontal disease. Results did not materially change when continuous variables of clinical attachment loss or pocket depth were used as outcomes. Although participants with periodontal disease had higher white blood cell and neutrophil counts, neutrophil counts were inversely related to OC pesticides (p for trend < 0.01). These inverse associations did not change after excluding subjects with C-reactive protein >/= 3 mg/L.
conclusionPOPs, especially OC pesticides, were positively associated with periodontal disease, possibly through immunomodulation due to OC pesticides.
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Registered trials
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