ArticlePLoS genetics2008
Evolutionary diversification of plant shikimate kinase gene duplicates.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Shikimate Kinase-Like 1 Participates in an Ancient and Conserved Role Contributing to Chloroplast Biogenesis in Land Plants.Molecular biology and evolution · 2025Article
- A Virulence Factor fromPlants (Basel, Switzerland) · 2024Article
- Evolution of aromatic amino acid metabolism in plants: a key driving force behind plant chemical diversity in aromatic natural products.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The Targeted Regulation of BDUbc and BDSKL1 Enhances Resistance to Blight inInternational journal of molecular sciences · 2024Article
- Overexpression of the maize genes ZmSKL1 and ZmSKL2 positively regulates drought stress tolerance in transgenic Arabidopsis.Plant cell reports · 2023Article
- Dissecting the biochemical and molecular-genetic regulation of diverse metabolic pathways governing aroma formation in indigenous aromatic indica rice varieties.Molecular biology reports · 2023Article
- Phenotypic and Genotypic Diversity of Roots Response to Salt in Durum Wheat Seedlings.Plants (Basel, Switzerland) · 2023Article
- Shikimate Kinase Plays Important Roles in Anthocyanin Synthesis in Petunia.International journal of molecular sciences · 2022Article
- Regulation of Drought and Salt Tolerance by OsSKL2 and OsASR1 in Rice.Rice (New York, N.Y.) · 2022Article
- Genomic Regions Associated With Seed Meal Quality Traits inFrontiers in plant science · 2022Article
- Identification of the interacting proteins ofFrontiers in plant science · 2022Article
- Transcriptome Profiling Reveals Molecular Changes during Flower Development between Male Sterile and Fertile Chinese Cabbage (Life (Basel, Switzerland) · 2021Article
- Auxins, the hidden player in chloroplast development.Plant cell reports · 2020Review
- Association Mapping of Seed Quality Traits Under Varying Conditions of Nitrogen Application inFrontiers in genetics · 2020Article
- An Insect Counteradaptation against Host Plant Defenses Evolved through Concerted Neofunctionalization.Molecular biology and evolution · 2019Article
- SKL1 Is Essential for Chloroplast Development in Arabidopsis.Frontiers in plant science · 2018Article
- Transcriptome comparisons shed light on the pre-condition and potential barrier for C4 photosynthesis evolution in eudicots.Plant molecular biology · 2016Article
- Positive Darwinian selection is a driving force for the diversification of terpenoid biosynthesis in the genus Oryza.BMC plant biology · 2014Article
- A comparative approach expands the protein-protein interaction node of the immune receptor XA21 in wheat and rice.Genome · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shikimate kinase (SK; EC 2.7.1.71) catalyzes the fifth reaction of the shikimate pathway, which directs carbon from the central metabolism pool to a broad range of secondary metabolites involved in plant development, growth, and stress responses. In this study, we demonstrate the role of plant SK gene duplicate evolution in the diversification of metabolic regulation and the acquisition of novel and physiologically essential function. Phylogenetic analysis of plant SK homologs resolves an orthologous cluster of plant SKs and two functionally distinct orthologous clusters. These previously undescribed genes, shikimate kinase-like 1 (SKL1) and -2 (SKL2), do not encode SK activity, are present in all major plant lineages, and apparently evolved under positive selection following SK gene duplication over 400 MYA. This is supported by functional assays using recombinant SK, SKL1, and SKL2 from Arabidopsis thaliana (At) and evolutionary analyses of the diversification of SK-catalytic and -substrate binding sites based on theoretical structure models. AtSKL1 mutants yield albino and novel variegated phenotypes, which indicate SKL1 is required for chloroplast biogenesis. Extant SKL2 sequences show a strong genetic signature of positive selection, which is enriched in a protein-protein interaction module not found in other SK homologs. We also report the first kinetic characterization of plant SKs and show that gene expression diversification among the AtSK inparalogs is correlated with developmental processes and stress responses. This study examines the functional diversification of ancient and recent plant SK gene duplicates and highlights the utility of SKs as scaffolds for functional innovation.
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