ArticlePloS one2008
Survival in nuclear waste, extreme resistance, and potential applications gleaned from the genome sequence of Kineococcus radiotolerans SRS30216.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
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- Genomic signatures of radiation stress adaptations inFrontiers in microbiology · 2026Article
- Metatranscriptomic analysis of colonic mucosal samples exploring the functional role of active microbial consortia in complicated diverticulitis.Microbiology spectrum · 2025Article
- Effects of simulated space environmental conditions on cleanroom microbes.Frontiers in microbiology · 2025Article
- Insights into the Impact of Physicochemical and Microbiological Parameters on the Safety Performance of Deep Geological Repositories.Microorganisms · 2024Review
- Association between the gut microbiome and carotenoid plumage phenotype in an avian hybrid zone.Proceedings. Biological sciences · 2024Article
- Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments.FEMS microbiology reviews · 2024Review
- Potential applications of microbial genomics in nuclear non-proliferation.Frontiers in microbiology · 2024Review
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- Characterization of radiation-resistance mechanism in Spirosoma montaniterrae DY10Scientific reports · 2023Article
- A Novel Actinobacterial Cutinase Containing a Noncatalytic Polymer-Binding Domain.Applied and environmental microbiology · 2022Article
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- Whole-genome bisulfite sequencing with improved accuracy and cost.Genome research · 2018Article
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- Genetic and Transcriptional Analyses of the Flagellar Gene Cluster in Actinoplanes missouriensis.Journal of bacteriology · 2016Article
- Novel genomic island modifies DNA with 7-deazaguanine derivatives.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The isolation and characterization of actinobacteria from dominant benthic macroinvertebrates endemic to Lake Baikal.Folia microbiologica · 2016Article
- From lithotroph- to organotroph-dominant: directional shift of microbial community in sulphidic tailings during phytostabilization.Scientific reports · 2015Article
- Complete genome sequence of the Radiation-Resistant bacterium Rubrobacter radiotolerans RSPS-4.Standards in genomic sciences · 2014Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kineococcus radiotolerans SRS30216 was isolated from a high-level radioactive environment at the Savannah River Site (SRS) and exhibits gamma-radiation resistance approaching that of Deinococcus radiodurans. The genome was sequenced by the U.S. Department of Energy's Joint Genome Institute which suggested the existence of three replicons, a 4.76 Mb linear chromosome, a 0.18 Mb linear plasmid, and a 12.92 Kb circular plasmid. Southern hybridization confirmed that the chromosome is linear. The K. radiotolerans genome sequence was examined to learn about the physiology of the organism with regard to ionizing radiation resistance, the potential for bioremediation of nuclear waste, and the dimorphic life cycle. K. radiotolerans may have a unique genetic toolbox for radiation protection as it lacks many of the genes known to confer radiation resistance in D. radiodurans. Additionally, genes involved in the detoxification of reactive oxygen species and the excision repair pathway are overrepresented. K. radiotolerans appears to lack degradation pathways for pervasive soil and groundwater pollutants. However, it can respire on two organic acids found in SRS high-level nuclear waste, formate and oxalate, which promote the survival of cells during prolonged periods of starvation. The dimorphic life cycle involves the production of motile zoospores. The flagellar biosynthesis genes are located on a motility island, though its regulation could not be fully discerned. These results highlight the remarkable ability of K radiotolerans to withstand environmental extremes and suggest that in situ bioremediation of organic complexants from high level radioactive waste may be feasible.
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