ArticlePloS one2008
Urinary alpha1-antichymotrypsin: a biomarker of prion infection.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Microglia contribute to polyG-dependent neurodegeneration in neuronal intranuclear inclusion disease.Acta neuropathologica · 2024Article
- Diagnosis in Scrapie: Conventional Methods and New Biomarkers.Pathogens (Basel, Switzerland) · 2023Review
- Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance.Journal of medicinal chemistry · 2022Article
- Serpin Signatures in Prion and Alzheimer's Diseases.Molecular neurobiology · 2022Article
- Comprehensive gene expression profiling of human astrocytes treated with a hepatic encephalopathy-inducible factor, alpha 1-antichymotripsin.Biochemistry and biophysics reports · 2020Article
- CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration.Annals of clinical and translational neurology · 2020Article
- Alterations in neuronal metabolism contribute to the pathogenesis of prion disease.Cell death and differentiation · 2018Article
- Differential overexpression of SERPINA3 in human prion diseases.Scientific reports · 2017Article
- Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.Prion · 2017Article
- Cystatin F is a biomarker of prion pathogenesis in mice.PloS one · 2017Article
- Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.BMC genomics · 2014Article
- Global protein differential expression profiling of cerebrospinal fluid samples pooled from Chinese sporadic CJD and non-CJD patients.Molecular neurobiology · 2014Article
- Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis.BMC research notes · 2013Article
- Presence of an acute phase response in sheep with clinical classical scrapie.BMC veterinary research · 2012Article
- Central nervous system gene expression changes in a transgenic mouse model for bovine spongiform encephalopathy.Veterinary research · 2011Article
- Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse.BMC genomics · 2010Article
- Application of "omics" to prion biomarker discovery.Journal of biomedicine & biotechnology · 2010Review
- Genomic and post-genomic analyses of human prion diseases.Genome medicine · 2009Article
- Movement disorders reveal Creutzfeldt-Jakob disease.Nature reviews. Neurology · 2009Article
- Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of blood-borne prion transmission incidents calls for identification of potential prion carriers. However, current methods for intravital diagnosis of prion disease rely on invasive tissue biopsies and are unsuitable for large-scale screening. Sensitive biomarkers may help meeting this need. Here we scanned the genome for transcripts elevated upon prion infection and encoding secreted proteins. We found that alpha(1)-antichymotrypsin (alpha(1)-ACT) was highly upregulated in brains of scrapie-infected mice. Furthermore, alpha(1)-ACT levels were dramatically increased in urine of patients suffering from sporadic Creutzfeldt-Jakob disease, and increased progressively throughout the disease. Increased alpha(1)-ACT excretion was also found in cases of natural prion disease of animals. Therefore measurement of urinary alpha(1)-ACT levels may be useful for monitoring the efficacy of therapeutic regimens for prion disease, and possibly also for deferring blood and organ donors that may be at risk of transmitting prion infections.
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