ArticleObesity (Silver Spring, Md.)2009
Severely obese have greater LPS-stimulated TNF-alpha production than normal weight African-American women.
Article in Obesity (Silver Spring, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Modulation of adipose inflammation and mitochondrial pathways by a yeast-derivedFrontiers in nutrition · 2025Article
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- Health Is Power: Active Transportation, Physical Activity, and Cardiometabolic Health Among Ethnic Minority Women.Journal of physical activity & health · 2020Article
- Combined training (strength plus aerobic) potentiates a reduction in body fat but only functional training reduced low-density lipoprotein cholesterol in postmenopausal women with a similar training load.Journal of exercise rehabilitation · 2017Article
- Consumption of a high-fat breakfast on consecutive days alters preclinical biomarkers for atherosclerosis.European journal of clinical nutrition · 2017Article
- Moderate rest intervals are superior to short intervals for improving PAI-1 following exhaustive exercise in recreational weightlifters.Journal of exercise rehabilitation · 2016Article
- Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- The association of binge eating and neighbourhood fast-food restaurant availability on diet and weight status.Public health nutrition · 2015Article
- Preventive effects of chitosan coacervate whey protein on body composition and immunometabolic aspect in obese mice.Mediators of inflammation · 2014Article
- Depression, stress and body fat are associated with binge eating in a community sample of African American and Hispanic women.Eating and weight disorders : EWD · 2013Article
- Relationship of fruit, vegetable, and fat consumption to binge eating symptoms in African American and Hispanic or Latina women.Eating behaviors · 2012Article
- Sitting time and cardiometabolic risk factors in african american overweight women.Journal of obesity · 2012Article
- Neighborhood factors influence physical activity among African American and Hispanic or Latina women.Health & place · 2012Article
- Analysis of body composition methods in a community sample of African American women.Women & health · 2011Article
- Article
- The role of moderate-to-vigorous physical activity in mediating the relationship between central adiposity and immunometabolic profile in postmenopausal women.Archives of endocrinology and metabolismArticle
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Authors and funding
3 authors.
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Abstract
Obesity is associated with an increase in chronic, low-grade inflammation which has been implicated in the development of type 2 diabetes mellitus and cardiovascular disease. The purpose of this study was to determine whether obesity was associated with an elevation of whole blood lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) production. African-American women were recruited from a larger study and assigned to one of five groups based on BMI: normal weight (NORM; BMI 20-25, n = 7), overweight (OVER; BMI 25-30, n = 12), class 1 obese (OB1; BMI 30-35, n = 19), class 2 obese (OB2; BMI 35-40, n = 10), or class 3 obese (OB3; BMI >40, n = 17). Body composition was determined via a whole body dual-energy X-ray absorptiometry (DXA) scan. Venous blood samples were collected following an overnight fast (>8 h), and stimulated with five doses of LPS (Salmonella enteriditis): 80, 40, 20, 10, and 5 microg/ml for 24 h in a 37 degrees C, 5% CO(2) incubator. Following stimulation, TNF-alpha was measured using enzyme-linked immunosorbent assay. OB3 produced 365% more TNF-alpha than NORM at an LPS dose of 20 microg/ml (P < 0.05). When maximal TNF-alpha production was assessed regardless of LPS dose, OB3 produced 230% more than NORM and OVER produced 190% more than NW (P = 0.001). Total and trunk fat mass and BMI were significantly correlated with maximal TNF-alpha production and LPS = 20 microg/ml. Our findings are consistent with previous reports suggesting a relationship between increased adiposity and inflammatory marker production. This is one of the first studies to focus on African-American women, who have higher rates of obesity.
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