ArticleThe Pediatric infectious disease journal2009
Streptococcal emm types in Hawaii: a region with high incidence of acute rheumatic fever.
Article in The Pediatric infectious disease journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization.Hawai'i journal of health & social welfare · 2020Article
- Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease.PLoS neglected tropical diseases · 2019Article
- Group A streptococcus endocarditis in children: 2 cases and a review of the literature.BMC infectious diseases · 2019Review
- Acute Rheumatic Carditis: A Rare Cause for Reversible Complete Heart Block.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2015Article
- Current insights in invasive group A streptococcal infections in pediatrics.European journal of pediatrics · 2012Review
- Lyme disease and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): an overview.International journal of general medicine · 2012Article
- Emergence of erythromycin- and clindamycin-resistant Streptococcus pyogenes emm 90 strains in Hawaii.Journal of clinical microbiology · 2011Article
- emm Type distribution pattern of group A streptococcus in north India: need for a new preventive approach.The Indian journal of medical research · 2010Article
- An insert in the covS gene distinguishes a pharyngeal and a blood isolate of Streptococcus pyogenes found in the same individual.Microbiology (Reading, England) · 2010Article
- No demonstrable effect of benzathine penicillin on recurrence of rheumatic Fever in pacific island population.Pediatric cardiology · 2010Article
- Higher rates of streptococcal colonization among children in the Pacific Rim Region correlates with higher rates of group A streptococcal disease and sequelae.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2010Article
- Clinical and microbial characteristics of invasive Streptococcus pyogenes disease in New Caledonia, a region in Oceania with a high incidence of acute rheumatic fever.Journal of clinical microbiology · 2010Article
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Authors and funding
6 authors.
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Abstract
backgroundThe clinical epidemiology of group A streptococcal (GAS) infections in Hawaii seems different from that in the continental United States with frequent skin infections and endemically high rates of acute rheumatic fever (ARF).
methodsGAS emm types in Hawaii were determined to identify any possible association between the emm types and specific clinical manifestations. A convenience sample of 1482 Hawaii GAS isolates collected between February 2000 and December 2005 was used. All isolates were characterized by emm sequence typing. The distribution of emm types in Hawaii was compared with the published continental US data for pharyngeal and invasive GAS strains, the CDC database from similar time periods, as well as with emm types present in a candidate GAS vaccine.
resultsNinety-three distinct emm types were recognized among the 1482 GAS isolates. The most frequently identified emm types in order of decreasing frequency were 12, 1, 28, 4, 22, 77, 81, 58, 65/69, 49, 74, 85, 92, 75, 101 and 2. Of this study sample, 27 of the 50 invasive GAS isolates belonged to uncommon continental US emm types (54% in Hawaii cultures vs. 10% reported from the continental US). Of the 1179 pharyngeal isolates, 509 belonged uncommon continental US emm types (43% in Hawaii cultures vs. 27% reported from the continental US).
conclusionsThe prevalent emm types in Hawaii differ from those in the continental US. The prevalence of these unusual emm types might limit the effectiveness of any proposed multivalent type-specific GAS vaccine in Hawaii.
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