SynthesisPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2009
Weaning and extubation readiness in pediatric patients.
Synthesis in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Ventilation-Weaning Protocols in Children Admitted to Pediatric Intensive Care Units: Systematic Review of Randomized Trials.Pediatric pulmonology · 2025Pooled it
- Guideline
- Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document.American journal of respiratory and critical care medicine · 2023Pooled it
- Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC).Intensive care medicine · 2017Guideline
- Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children.The Cochrane database of systematic reviews · 2014Pooled it
- Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in critically ill paediatric patients.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Trial
- Effect of pediatric ventilation weaning technique on work of breathing.Respiratory research · 2022Trial
- Neurally adjusted ventilatory assist (NAVA) allows patient-ventilator synchrony during pediatric noninvasive ventilation: a crossover physiological study.Critical care (London, England) · 2015Trial
- Remifentanil and propofol for weaning of mechanically ventilated pediatric intensive care patients.European journal of pediatrics · 2011Trial
- Machine Learning-Based Prediction of 48-Hour Extubation Success in Mechanically Ventilated Children: A Single-Center Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Evaluating the Association of Extubation Readiness Testing Performance Variables With Reintubation After Pediatric Cardiac Surgery.Respiratory care · 2026Article
- Risk factors analysis for extubation failure following mandibular distraction osteogenesis in infants with Pierre Robin sequence: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Integrated lung-diaphragm ultrasound in pediatric weaning assessment: a mini review.Frontiers in pediatrics · 2026Review
- Expert-augmented machine learning for predicting extubation readiness in the pediatric intensive care unit.BMC medical informatics and decision making · 2025Article
- Transcutaneous Carbon Dioxide Monitoring During Weaning From Mechanical Ventilation in Children: The WeanCOPediatric pulmonology · 2025Article
- Extubation Failure and Timing to Tracheostomy in Children Surviving Acute Neurological Injury.Children (Basel, Switzerland) · 2025Article
- Article
- Impact of extubation failure on the duration of mechanical ventilation in the pediatric population.Einstein (Sao Paulo, Brazil) · 2025Observational
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveA systematic review of weaning and extubation for pediatric patients on mechanical ventilation. DATA SELECTION: Pediatric and adult literature, English language. STUDY SELECTION: Invited review. DATA SOURCES: Literature review using National Library of Medicine PubMed from January 1972 until April 2008, earlier cross-referenced article citations, the Cochrane Database of Systematic Reviews, and the Internet.
conclusionsDespite the importance of minimizing time on mechanical ventilation, only limited guidance on weaning and extubation is available from the pediatric literature. A significant proportion of patients being evaluated for weaning are actually ready for extubation, suggesting that weaning is often not considered early enough in the course of ventilation. Indications for extubation are even less clear, although a trial of spontaneous breathing would seem a prerequisite. Several indices have been developed in an attempt to predict weaning and extubation success but the available literature would suggest they offer no improvement over clinical judgment. Extubation failure rates range from 2% to 20% and bear little relationship to the duration of mechanical ventilation. Upper airway obstruction is the single most common cause of extubation failure. A reliable method of assessing readiness for weaning and predicting extubation success is not evident from the pediatric literature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.