ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Does attenuated skin blood flow lower sweat rate and the critical environmental limit for heat balance during severe heat exposure?Experimental physiology · 2017Trial
- The effect of type-2-diabetes-related vascular endothelial dysfunction on skin physiology and activities of daily living.Journal of diabetes science and technology · 2011Trial
- Women with a history of gestational diabetes mellitus have preserved sensory nerve-mediated dilatation in the cutaneous microvasculature.Experimental physiology · 2026Article
- Diabetic Wound Vasculopathy and Neuropathy: Spotlight on Wound Lipid Signaling.Advances in wound care · 2026Review
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Vascular nitric oxide resistance in type 2 diabetes.Cell death & disease · 2023Review
- The Association between Apparent Temperature and Hospital Admissions for Cardiovascular Disease in Limpopo Province, South Africa.International journal of environmental research and public health · 2022Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Effect of enriched oxygen inhalation on lower limb skin temperatures in diabetic and healthy humans: a pilot study.Diving and hyperbaric medicine · 2022Article
- Contributions of endothelin-1 and l-arginine to blunted cutaneous microvascular function in young, black women.American journal of physiology. Heart and circulatory physiology · 2022Article
- Type 2 diabetes does not exacerbate body heat storage in older adults during brief, extreme passive heat exposure.Temperature (Austin, Tex.) · 2020Article
- Chronic statin therapy is associated with enhanced cutaneous vascular responsiveness to sympathetic outflow during passive heat stress.The Journal of physiology · 2019Article
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Autonomic control of body temperature and blood pressure: influences of female sex hormones.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
- No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat.Physiological reports · 2017Article
- The thermoregulation of healthy individuals, overweight-obese, and diabetic from the plantar skin thermogram: a clue to predict the diabetic foot.Diabetic foot & ankle · 2017Review
- Current concepts of active vasodilation in human skin.Temperature (Austin, Tex.) · 2017Review
- Sympathetic regulation during thermal stress in human aging and disease.Autonomic neuroscience : basic & clinical · 2016Review
- Comparison of the noradrenergic sympathetic nerve contribution during local skin heating at forearm and leg sites in humans.European journal of applied physiology · 2015Article
- Increased leg blood flow and improved femoral artery shear patterns in metabolic syndrome after a diet and exercise programme.Clinical physiology and functional imaging · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Individuals with type 2 diabetes mellitus (T2DM) often exhibit microvascular dysfunction that may contribute to impaired thermoregulation, but potential mechanisms remain unclear. Our goals were to quantify skin blood flow responses and nitric oxide-mediated vasodilation during body heating in individuals with T2DM compared with nondiabetic control subjects of similar age. We measured skin blood flow (laser-Doppler flowmetry) in conjunction with intradermal microdialysis of N(G)-nitro-l-arginine methyl ester (l-NAME; nitric oxide synthase inhibitor) or vehicle during 45-60 min of whole body heating (WBH) in 10 individuals with T2DM and 14 control subjects. In six individuals from each group, we also measured forearm blood flow (FBF) by venous occlusion plethysmography on the contralateral forearm. FBF responses showed diminished absolute cutaneous vasodilation during WBH in the T2DM group (P(ANOVA) < 0.01; peak FBF in control 13.1 +/- 1.7 vs. T2DM 9.0 +/- 1.6 ml.100 ml(-1).min(-1)). However, the relative contribution of nitric oxide to the cutaneous vasodilator response (expressed as % of maximal cutaneous vascular conductance) was not different between groups (P > 0.05). We conclude that cutaneous vasodilator responses to WBH are decreased in individuals with T2DM, but the contribution of nitric oxide to this smaller vasodilation is similar between T2DM and control individuals. This decrease in cutaneous vasodilation is likely an important contributor to impaired thermoregulation in T2DM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.