ArticleGenes & development2008
Release of yeast telomeres from the nuclear periphery is triggered by replication and maintained by suppression of Ku-mediated anchoring.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Telomeres in mitosis: organization and dynamics.Nucleus (Austin, Tex.) · 2026Review
- Ctf18-dependent localization of interstitial telomeric sequence to nuclear pore complexes prevents chromosome fragility.Nucleic acids research · 2026Article
- Mitotic kinase regulation of DNA replication forks.bioRxiv : the preprint server for biology · 2026Article
- Phosphorylation-dependent mitotic SUMOylation drives nuclear envelope-chromatin interactions.The Journal of cell biology · 2021Article
- Telomere Replication: Solving Multiple End Replication Problems.Frontiers in cell and developmental biology · 2021Review
- Yeast epigenetics: the inheritance of histone modification states.Bioscience reports · 2019Review
- Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.Nucleic acids research · 2018Article
- Yeast silencing factor Sir4 and a subset of nucleoporins form a complex distinct from nuclear pore complexes.The Journal of cell biology · 2017Article
- Expression of Subtelomeric lncRNAs Links Telomeres Dynamics to RNA Decay inNon-coding RNA · 2015Article
- Getting down to the core of histone modifications.Chromosoma · 2014Review
- The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.The Journal of cell biology · 2013Article
- An auxiliary, membrane-based mechanism for nuclear migration in budding yeast.Molecular biology of the cell · 2013Article
- Article
- Location, location, location: it's all in the timing for replication origins.Genes & development · 2013Review
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- TFIIIC localizes budding yeast ETC sites to the nuclear periphery.Molecular biology of the cell · 2012Article
- Ribosome biogenesis factors bind a nuclear envelope SUN domain protein to cluster yeast telomeres.The EMBO journal · 2011Article
- An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.The Journal of biological chemistry · 2011Article
- Gene positioning is regulated by phosphorylation of the nuclear pore complex by Cdk1.Cell cycle (Georgetown, Tex.) · 2011Article
- Cdk phosphorylation of a nucleoporin controls localization of active genes through the cell cycle.Molecular biology of the cell · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The perinuclear localization of Saccharomyces cerevisiae telomeres provides a useful model for studying mechanisms that control chromosome positioning. Telomeres tend to be localized at the nuclear periphery during early interphase, but following S phase they delocalize and remain randomly positioned within the nucleus. We investigated whether DNA replication causes telomere delocalization from the nuclear periphery. Using live-cell fluorescence microscopy, we show that delaying DNA replication causes a corresponding delay in the dislodgment of telomeres from the nuclear envelope, demonstrating that replication of individual telomeres causes their delocalization. Telomere delocalization is not simply the result of recruitment to a replication factory in the nuclear interior, since we found that telomeric DNA replication can occur either at the nuclear periphery or in the nuclear interior. The telomere-binding complex Ku is one of the factors that localizes telomeres to the nuclear envelope. Using a gene locus tethering assay, we show that Ku-mediated peripheral positioning is switched off after DNA replication. Based on these findings, we propose that DNA replication causes telomere delocalization by triggering stable repression of the Ku-mediated anchoring pathway. In addition to maintaining genetic information, DNA replication may therefore regulate subnuclear organization of chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.