ArticleThe Journal of nutrition2009
Biotin sensing at the molecular level.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- New Potent Sulfonamide-Based Inhibitors ofACS medicinal chemistry letters · 2024Article
- XRE-Type Regulator BioX Acts as a Negative Transcriptional Factor of Biotin Metabolism in Riemerella anatipestifer.Journal of bacteriology · 2021Article
- Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway.Nature communications · 2021Article
- Article
- Biotin Protein Ligase Is a Target for New Antibacterials.Antibiotics (Basel, Switzerland) · 2016Review
- Functional definition of BirA suggests a biotin utilization pathway in the zoonotic pathogen Streptococcus suis.Scientific reports · 2016Article
- Mechanisms of biotin-regulated gene expression in microbes.Synthetic and systems biotechnology · 2016Review
- Paracoccus denitrificans possesses two BioR homologs having a role in regulation of biotin metabolism.MicrobiologyOpen · 2015Article
- Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection.Nature communications · 2015Article
- Successful conversion of the Bacillus subtilis BirA Group II biotin protein ligase into a Group I ligase.PloS one · 2014Article
- A Francisella virulence factor catalyses an essential reaction of biotin synthesis.Molecular microbiology · 2014Article
- Brucella BioR regulator defines a complex regulatory mechanism for bacterial biotin metabolism.Journal of bacteriology · 2013Article
- Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target.Protein science : a publication of the Protein Society · 2013Article
- Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase.ACS medicinal chemistry letters · 2012Article
- Phylogenetic analysis of Bacillus subtilis strains applicable to natto (fermented soybean) production.Applied and environmental microbiology · 2011Article
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- Article
- Cell and molecular aspects of human intestinal biotin absorption.The Journal of nutrition · 2009Article
- Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human Jurkat lymphoblastoma cells.The Journal of nutrition · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Biotin influences transcription in organisms from bacteria to humans. The enzyme, biotin protein ligase, which catalyzes post-transcriptional biotin addition to biotin-dependent carboxylases, plays a central roll in transmitting the demand for biotin to gene expression. The molecular mechanism of this communication in bacteria is well understood and involves competing protein:protein interactions. Biochemical measurements indicate that this competition is kinetically controlled. In humans, the biochemistry of biotin sensing at the transcriptional level is not well characterized. However, the biotin holoenzyme ligase (holocarboxylase synthetase) is proposed to both catalyze biotin addition to carboxylases and to histones in its metabolic and transcriptional roles, respectively. Control of human holocarboxylase synthetase function is, however, considerably more complex than the simple competitive protein protein interactions observed in bacterial systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.