SynthesisInternational journal of epidemiology2009
Seasonality of rotavirus disease in the tropics: a systematic review and meta-analysis.
Synthesis in International journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03602053 (An Open-label, Randomized, Controlled, Single Centre, Phase IIb Study to Assess the Immunogenicity, Reactogenicity and Safety of Three Live Oral Rotavirus Vaccines, ROTAVAC® , ROTAVAC 5CM and Rotarix® in Healthy Zambian Infants), which is not on this map. Cited by 151 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open-label, Randomized, Controlled, Single Centre, Phase IIb Study to Assess the Immunogenicity, Reactogenicity and Safety of Three Live Oral Rotavirus Vaccines, ROTAVAC® , ROTAVAC 5CM and Rotarix® in Healthy Zambian Infants
Who cites it
151 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Rainfall and Temperature Influences on Childhood Diarrhea and the Effect Modification Role of Water and Sanitation Conditions: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2024Pooled it
- Epidemiology of Rotavirus in Humans, Animals, and the Environment in Africa: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2024Pooled it
- Temperature and risk of infectious diarrhea: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Modeling environmentally mediated rotavirus transmission: The role of temperature and hydrologic factors.Proceedings of the National Academy of Sciences of the United States of America · 2018Pooled it
- Climatic Drivers of Diarrheagenic Escherichia coli Incidence: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2016Pooled it
- Untangling the Impacts of Climate Change on Waterborne Diseases: a Systematic Review of Relationships between Diarrheal Diseases and Temperature, Rainfall, Flooding, and Drought.Environmental science & technology · 2016Pooled it
- A systematic review and meta-analysis of ambient temperature and diarrhoeal diseases.International journal of epidemiology · 2016Pooled it
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- Longitudinal Effects of a Sanitation Intervention on Environmental Fecal Contamination in a Cluster-Randomized Controlled Trial in Rural Bangladesh.Environmental science & technology · 2021Trial
- Effects of Single and Combined Water, Sanitation and Handwashing Interventions on Fecal Contamination in the Domestic Environment: A Cluster-Randomized Controlled Trial in Rural Bangladesh.Environmental science & technology · 2018Trial
- Rotavirus seasonal distribution and prevalence before and after the introduction of rotavirus vaccine in a peri-urban community of Lima, Peru.The American journal of tropical medicine and hygiene · 2015Trial
- Genetic diversity of circulating rotavirus strains in Tanzania prior to the introduction of vaccination.PloS one · 2014Trial
- Effects of climatic factors on rotavirus infection in Bangladesh: a time series analysis and future projections.Global health action · 2026Article
- Association Between Weather Variables and Viral Gastroenteritis in the United States.Open forum infectious diseases · 2026Article
- Post-pandemic rebound of rotavirus and adenovirus in pediatric gastroenteritis: a 6-year antigen-based surveillance study from Turkey.Wiener medizinische Wochenschrift (1946) · 2026Article
- Exploring the Relationship Between Respiratory Syncytial Virus and Asthma Using Calendar Time at Birth as a Source of Quasi-Random Variation.Paediatric and perinatal epidemiology · 2026Article
- Vulnerability to climate-driven pathogen-specific diarrheal diseases: secondary analysis from the Global Enteric Multicenter Study and Vaccine Impact on Diarrhea in Africa follow-up.Nature communications · 2026Article
- Epidemiology and Clinical Impact of Pediatric Viral Gastroenteritis Before and After Rotavirus Vaccination in Sicily.Pathogens (Basel, Switzerland) · 2026Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundTo date little conclusive evidence exists on the seasonality of rotavirus incidence in the tropics. We present a systematic review and meta-analysis on the seasonal epidemiology of rotavirus in the tropics, including 26 studies reporting continuous monthly rotavirus incidence for which corresponding climatological data was available.
methodsUsing linear regression models that account for serial correlation between months, monthly rotavirus incidence was significantly negatively correlated with temperature, rainfall and relative humidity in 65%, 55% and 60% of studies, respectively. We carried out pooled analyses using a generalized estimating equation (GEE) that accounts for correlation from between-study variation and serial correlation between months within a given study.
resultsFor every 1 degrees C (1.8 degrees F) increase in mean temperature, 1 cm (0.39 in.) increase in mean monthly rainfall, and 1% increase in relative humidity (22%) this analysis showed reductions in rotavirus incidence of 10% (95% CI: 6-13%), 1% (95% CI: 0-1%), and 3% (95% CI:0-5%), respectively.
conclusionsOn the basis of the evidence, we conclude that rotavirus responds to changes in climate in the tropics, with the highest number of infections found at the colder and drier times of the year.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.