ArticleThe Journal of biological chemistry2009
Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Modeling the Pro-inflammatory Tumor Microenvironment in Acute Lymphoblastic Leukemia Predicts a Breakdown of Hematopoietic-Mesenchymal Communication Networks.Frontiers in physiology · 2016Article
- Role of miR-155 in drug resistance of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.The Journal of clinical investigation · 2013Article
- Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.The Journal of biological chemistry · 2011Article
- Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.The Journal of clinical investigation · 2010Article
- MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer.The Journal of biological chemistry · 2010Article
- FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Pro-apoptotic protein 24p3, a member of lipocalin family, is induced upon interleukin-3 (IL-3) deprivation and plays a pivotal role in induction of apoptosis in hematopoietic cells. However, the molecular mechanism by which IL-3 regulates 24p3 expression remains largely unknown. Here, we show that 24p3 is a direct target of Foxo3a and that phosphoinositide 3-kinase (PI3K)/Akt mediates IL-3-repressed 24p3 through regulation of Foxo3a. Inhibition of the PI3K/Akt (but not MAPK) pathway induced 24p3 expression and programmed cell death in FL5.12 cells. Furthermore, constitutively active Akt largely attenuated 24p3 expression and apoptosis in response to IL-3 withdrawal. Foxo3a directly bound to the 24p3 promoter and induced promoter activity. Akt abrogated wild-type Foxo3a-induced (but not Akt-non-phosphorylatable Foxo3a3A-induced) 24p3 expression and promoter activity. Therefore, these data indicate for the first time that 24p3 is a Foxo3a target gene and that PI3K/Akt (but not MAPK) mediates IL-3-regulated 24p3 expression in hematopoietic cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.