ArticleMolecular biology of the cell2009
Basal body components exhibit differential protein dynamics during nascent basal body assembly.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections.The Journal of cell biology · 2024Article
- Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections.bioRxiv : the preprint server for biology · 2023Article
- Basal body organization and cell geometry during the cell cycle inMolecular biology of the cell · 2023Article
- With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making.Cells · 2020Review
- Microtubule glycylation promotes attachment of basal bodies to the cell cortex.Journal of cell science · 2019Article
- BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.Journal of cell science · 2019Article
- Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism.eLife · 2019Article
- Building the right centriole for each cell type.The Journal of cell biology · 2018Review
- Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays.Biology open · 2015Article
- Tetrahymena basal bodies.Cilia · 2015Review
- Centriole structure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Choosing sides--asymmetric centriole and basal body assembly.Journal of cell science · 2014Review
- Site-specific basal body duplication in Chlamydomonas.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat.PloS one · 2014Article
- ε-tubulin is essential in Tetrahymena thermophila for the assembly and stability of basal bodies.Journal of cell science · 2013Article
- Sfr13, a member of a large family of asymmetrically localized Sfi1-repeat proteins, is important for basal body separation and stability in Tetrahymena thermophila.Journal of cell science · 2013Article
- Article
- The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies.Molecular biology of the cell · 2012Article
- Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces.Molecular biology of the cell · 2012Article
- The two domains of centrin have distinct basal body functions in Tetrahymena.Molecular biology of the cell · 2011Article
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3 authors.
Funding
Abstract
Basal bodies organize cilia that are responsible for both mechanical beating and sensation. Nascent basal body assembly follows a series of well characterized morphological events; however, the proteins and their assembly dynamics for new basal body formation and function are not well understood. High-resolution light and electron microscopy studies were performed in Tetrahymena thermophila to determine how proteins assemble into the structure. We identify unique dynamics at basal bodies for each of the four proteins analyzed (alpha-tubulin, Spag6, centrin, and Sas6a). alpha-Tubulin incorporates only during new basal body assembly, Spag6 continuously exchanges at basal bodies, and centrin and Sas6a exhibit both of these patterns. Centrin loads and exchanges at the basal body distal end and stably incorporates during new basal body assembly at the nascent site of assembly and the microtubule cylinder. Conversely, both dynamic and stable populations of Sas6a are found only at a single site, the cartwheel. The bimodal dynamics found for centrin and Sas6a reveal unique protein assembly mechanisms at basal bodies that may reflect novel functions for these important basal body and centriolar proteins.
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