ArticleThe Journal of nutrition2009
Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.The Journal of nutrition · 2014Trial
- Review
- Dynamic characterization of the changes in intestinal fungi and fecal metabolites during the reproductive cycle of sows.Veterinary research communications · 2025Article
- Associations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq.Obstetrics and gynecology international · 2025Article
- Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice.Metabolites · 2024Article
- Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients.Maternal health, neonatology and perinatology · 2022Review
- Relevance of Biotin Deficiency in Patients with Inflammatory Bowel Disease and Utility of Serum 3 Hydroxyisovaleryl Carnitine as a Practical Everyday Marker.Journal of clinical medicine · 2022Article
- The biotin interference within interference suppressed immunoassays.Journal of clinical laboratory analysis · 2021Article
- Nutrients, Mitochondrial Function, and Perinatal Health.Nutrients · 2020Review
- Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential.Clinics (Sao Paulo, Brazil) · 2019Review
- The biotin-ligating protein BPL-1 is critical for lipid biosynthesis and polarization of theThe Journal of biological chemistry · 2018Article
- Biotin: From Nutrition to Therapeutics.The Journal of nutrition · 2017Review
- In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency.The Journal of nutrition · 2015Article
- Adequate intake of biotin in pregnancy: why bother?The Journal of nutrition · 2014Article
- Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans.The Journal of nutrition · 2012Article
- Supplementation of biotin to sperm preparation medium increases the motility and longevity in cryopreserved human spermatozoa.Journal of assisted reproduction and genetics · 2012Article
- Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS.Analytical and bioanalytical chemistry · 2011Article
- Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.The Journal of nutrition · 2011Article
- The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events.Epigenetics · 2011Article
- Urinary excretion of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans.The Journal of nutrition · 2011Article
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Abstract
In studies of marginal biotin deficiency induced experimentally in adults, increased urinary excretion of 3-hydroxyisovaleric acid (3HIA), which likely reflects decreased activity of the biotin-dependent enzyme beta-methylcrotonyl-CoA carboxylase, and decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase (PCC) in peripheral blood lymphocytes have been validated as indices of biotin status. About half of pregnant women excrete increased amounts of urinary 3HIA. However, interpretation of urinary 3HIA excretion rates is problematic, because renal function is altered by pregnancy per se. In a recent pilot study, activity of PCC in peripheral blood lymphocytes was decreased in 18 of 22 pregnant women. In 4 of 4 pregnant women with decreased PCC activity, biotin supplementation caused increased PCC activity by a mean of 95%. Taken together, such studies provide evidence that a substantial proportion of pregnant women are marginally biotin deficient. In mice, degrees of biotin deficiency that are metabolically similar to those seen in pregnant women are very teratogenic. Moreover, in mice, a marginal degree of biotin deficiency in the dam causes a much more severe degree of deficiency in the fetus. These observations further raise concerns that biotin deficiency does occur and does cause human birth defects.
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