ArticleRespiratory physiology & neurobiology2009
Development of chemosensitivity in neurons from the nucleus tractus solitarii (NTS) of neonatal rats.
Article in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract.Pflugers Archiv : European journal of physiology · 2020Article
- Brainstem catecholaminergic neurones and breathing control during postnatal development in male and female rats.The Journal of physiology · 2018Article
- Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats.The Journal of physiology · 2018Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Ventilatory and chemoreceptor responses to hypercapnia in neonatal rats chronically exposed to moderate hyperoxia.Respiratory physiology & neurobiology · 2017Article
- Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis.Comprehensive Physiology · 2016Review
- Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats.Neuroscience · 2016Article
- Blockade of Na+/H+ exchanger type 3 causes intracellular acidification and hyperexcitability via inhibition of pH-sensitive K+ channels in chemosensitive respiratory neurons of the dorsal vagal nucleus in rats.Neuroscience bulletin · 2014Article
- Serotonin neurons and central respiratory chemoreception: where are we now?Progress in brain research · 2014Review
- Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.PloS one · 2014Article
- Transient outwardly rectifying A currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Neonatal hypoxic insult-mediated cholinergic disturbances in the brain stem: effect of glucose, oxygen and epinephrine resuscitation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Fatal breathing dysfunction in a mouse model of Leigh syndrome.The Journal of clinical investigation · 2012Article
- The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate.Respiratory physiology & neurobiology · 2010Review
- The locus coeruleus and central chemosensitivity.Respiratory physiology & neurobiology · 2010Review
- Medullary serotonin neurons and their roles in central respiratory chemoreception.Respiratory physiology & neurobiology · 2010Review
- Central respiratory chemoreception.The Journal of comparative neurology · 2010Review
- CO2 chemoreception in cardiorespiratory control.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
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5 authors at 2 institutions in 1 country.
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Abstract
We studied the development of chemosensitivity during the neonatal period in rat nucleus tractus solitarii (NTS) neurons. We determined the percentage of neurons activated by hypercapnia (15% CO(2)) and assessed the magnitude of the response by calculating the chemosensitivity index (CI). There were no differences in the percentage of neurons that were inhibited (9%) or activated (44.8%) by hypercapnia or in the magnitude of the activated response (CI 164+/-4.9%) in NTS neurons from neonatal rats of all ages. To assess the degree of intrinsic chemosensitivity in these neurons we used chemical synaptic block medium and the gap junction blocker carbenoxolone. Chemical synaptic block medium slightly decreased basal firing rate but did not affect the percentage of NTS neurons that responded to hypercapnia at any neonatal age. However, in neonates aged <P10, but not in older neonates, chemical synaptic block medium increased CI. Carbenoxolone did not significantly alter the number of NTS neurons activated by hypercapnia in neonatal rats of any age. In summary, the response of NTS neurons from neonatal rats appears to be intrinsic and largely unchanged throughout early development. In young neonates (<P10) chemical synaptic input reduces the magnitude of the firing rate response to hypercapnia, but otherwise neither chemical synaptic input nor gap junctions significantly alter the percentage of NTS neurons that respond to hypercapnia or the magnitude of that response.
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