ArticleGene expression patterns : GEP2009
Conserved sequence block clustering and flanking inter-cluster flexibility delineate enhancers that regulate nerfin-1 expression during Drosophila CNS development.
Article in Gene expression patterns : GEP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Ultraconserved Non-coding DNA Within Diptera and Hymenoptera.G3 (Bethesda, Md.) · 2020Article
- cis-regulatory analysis of the Drosophila pdm locus reveals a diversity of neural enhancers.BMC genomics · 2015Article
- Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes.Cell reports · 2015Article
- In silico evolution of the hunchback gene indicates redundancy in cis-regulatory organization and spatial gene expression.Journal of bioinformatics and computational biology · 2014Article
- Article
- Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired.Developmental biology · 2012Article
- Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers.Gene expression patterns : GEPArticle
- Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer.Mechanisms of developmentArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
We have identified clusters of conserved sequences constituting discrete modular enhancers within the Drosophilanerfin-1 locus. nerfin-1 encodes a Zn-finger transcription factor that directs pioneer interneuron axon guidance. nerfin-1 mRNA is detected in many early delaminating neuroblasts, ganglion mother cells and transiently in nascent neurons. The comparative genomics analysis program EvoPrinter revealed conserved sequence blocks both upstream and downstream of the transcribed region. By using the aligning regions of different drosophilids as the reference DNA, EvoPrinter detects sequence length flexibility between clusters of conserved sequences and thus facilitates differentiation between closely associated modular enhancers. Expression analysis of enhancer-reporter transgenes identified enhancers that drive expression in different regions of the developing embryonic and adult nervous system, including subsets of embryonic CNS neuroblasts, GMCs, neurons and PNS neurons. In summary, EvoPrinter facilitates the discovery and analysis of enhancers that control crucial aspects of nerfin-1 expression.
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