ArticleMalaria journal2008
Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.Malaria journal · 2023Trial
- Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon.Pathogens and global health · 2014Trial
- Review
- Genetic variants, gene expression, and soluble CD36 analysis in acute coronary syndrome: Differential protein concentration between ST-segment elevation myocardial infarction and unstable angina.Journal of clinical laboratory analysis · 2022Article
- Sequencing and comparative genome analysis of three Indians.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria.Science advances · 2021Article
- Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population.Molecular biology reports · 2020Article
- Genomics of rare genetic diseases-experiences from India.Human genomics · 2019Review
- Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2017Article
- Association of PECAM1/CD31 polymorphisms with cerebral malaria.International journal of molecular epidemiology and genetics · 2016Article
- Polymorphisms in host genes encoding NOSII, C-reactive protein, and adhesion molecules thrombospondin and E-selectin are risk factors for Plasmodium falciparum malaria in India.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Polymorphisms in the intercellular adhesion molecule 1 gene and cancer risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Identification of protein markers in patients infected with Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax.International journal of molecular sciences · 2014Article
- Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.Genes and immunity · 2012Article
- Sequencing and analysis of a South Asian-Indian personal genome.BMC genomics · 2012Article
- The host genetic diversity in malaria infection.Journal of tropical medicine · 2012Article
- Article
- Genetic polymorphisms linked to susceptibility to malaria.Malaria journal · 2011Review
- IGVBrowser--a genomic variation resource from diverse Indian populations.Database : the journal of biological databases and curation · 2010Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHost adhesion molecules play a significant role in the pathogenesis of Plasmodium falciparum malaria and changes in their structure or levels in individuals can influence the outcome of infection. The aim of this study was to investigate the association of SNPs of three adhesion molecule genes, ICAM1, PECAM1 and CD36, with severity of falciparum malaria in a malaria-endemic and a non-endemic region of India.
methodsThe frequency distribution of seven selected SNPs of ICAM1, PECAM1 and CD36 was determined in 552 individuals drawn from 24 populations across India. SNP-disease association was analysed in a case-control study format. Genotyping of the population panel was performed by Sequenom mass spectroscopy and patient/control samples were genotyped by SNaPshot method. Haplotypes and linkage disequilibrium (LD) plots were generated using PHASE and Haploview, respectively. Odds-ratio (OR) for risk assessment was estimated using EpiInfotrade mark version 3.4.
resultsAssociation of the ICAM1 rs5498 (exon 6) G allele and the CD36 exon 1a A allele with increased risk of severe malaria was observed (severe versus control, OR = 1.91 and 2.66, P = 0.02 and 0.0012, respectively). The CD36 rs1334512 (-53) T allele as well as the TT genotype associated with protection from severe disease (severe versus control, TT versus GG, OR = 0.37, P = 0.004). Interestingly, a SNP of the PECAM1 gene (rs668, exon 3, C/G) with low minor allele frequency in populations of the endemic region compared to the non-endemic region exhibited differential association with disease in these regions; the G allele was a risk factor for malaria in the endemic region, but exhibited significant association with protection from disease in the non-endemic region.
conclusionThe data highlights the significance of variations in the ICAM1, PECAM1 and CD36 genes in the manifestation of falciparum malaria in India. The PECAM1 exon 3 SNP exhibits altered association with disease in the endemic and non-endemic region.
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