ArticleBMC microbiology2008
Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic potential structures gill symbiont communities in two common shipworm species.The ISME journal · 2026Article
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- The oxidative stress response, in particular the katY gene, is temperature-regulated in Yersinia pseudotuberculosis.PLoS genetics · 2023Article
- High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis.BMC microbiology · 2018Article
- The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal.Acta crystallographica. Section D, Structural biology · 2017Article
- Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sites.Acta crystallographica. Section D, Structural biology · 2017Article
- Identification of New Virulence Factors and Vaccine Candidates forFrontiers in cellular and infection microbiology · 2017Article
- Environmental Regulation of Yersinia Pathophysiology.Frontiers in cellular and infection microbiology · 2016Review
- Yersinia Type III Secretion System Master Regulator LcrF.Journal of bacteriology · 2015Review
- Comparative genomics of closely related Salmonella enterica serovar Typhi strains reveals genome dynamics and the acquisition of novel pathogenic elements.BMC genomics · 2014Article
- Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae.Frontiers in cellular and infection microbiology · 2014Review
- Global gene expression changes in Candidatus Liberibacter asiaticus during the transmission in distinct hosts between plant and insect.Molecular plant pathology · 2013Article
- Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection.PLoS pathogens · 2013Article
- Hunger for iron: the alternative siderophore iron scavenging systems in highly virulent Yersinia.Frontiers in cellular and infection microbiology · 2012Review
- Effects of orange juice pH on survival, urease activity and DNA profiles of Yersinia enterocolitica and Yersinia pseudotuberculosis stored at 4 degree C.Journal of food safety · 2011Article
- Article
- The small RNA chaperone Hfq is required for the virulence of Yersinia pseudotuberculosis.Infection and immunity · 2010Article
- Global transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum.BMC microbiology · 2010Article
- Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans.PLoS pathogens · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn man, infection by the Gram-negative enteropathogen Yersinia pseudotuberculosis is usually limited to the terminal ileum. However, in immunocompromised patients, the microorganism may disseminate from the digestive tract and thus cause a systemic infection with septicemia.
resultsTo gain insight into the metabolic pathways and virulence factors expressed by the bacterium at the blood stage of pseudotuberculosis, we compared the overall gene transcription patterns (the transcriptome) of bacterial cells cultured in either human plasma or Luria-Bertani medium. The most marked plasma-triggered metabolic consequence in Y. pseudotuberculosis was the switch to high glucose consumption, which is reminiscent of the acetogenic pathway (known as "glucose overflow") in Escherichia coli. However, upregulation of the glyoxylate shunt enzymes suggests that (in contrast to E. coli) acetate may be further metabolized in Y. pseudotuberculosis. Our data also indicate that the bloodstream environment can regulate major virulence genes (positively or negatively); the yadA adhesin gene and most of the transcriptional units of the pYV-encoded type III secretion apparatus were found to be upregulated, whereas transcription of the pH6 antigen locus was strongly repressed.
conclusionOur results suggest that plasma growth of Y. pseudotuberculosis is responsible for major transcriptional regulatory events and prompts key metabolic reorientations within the bacterium, which may in turn have an impact on virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.