ArticleClinical chemistry and laboratory medicine2009
Aging and endothelial progenitor cell telomere length in healthy men.
Article in Clinical chemistry and laboratory medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study.BMC cardiovascular disorders · 2013Trial
- Renovascular Disease and Its Impact on Endogenous Kidney Repair: Stem/Progenitor Cells.Stem cells international · 2026Review
- Association between telomere length and erectile dysfunction: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Senescent cells: a therapeutic target for cardiovascular disease.The Journal of clinical investigation · 2018Review
- Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.Current cardiology reviews · 2018Review
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- Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.Oxidative medicine and cellular longevity · 2016Review
- Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways.British journal of pharmacology · 2014Article
- The endothelium abridges insulin resistance to premature aging.Journal of the American Heart Association · 2013Review
- Mechanisms involved in the aging-induced vascular dysfunction.Frontiers in physiology · 2012Article
- Endothelial progenitor cells enter the aging arena.Frontiers in physiology · 2012Article
- Genetic and clinical correlates of early-outgrowth colony-forming units.Circulation. Cardiovascular genetics · 2011Article
- Aging is associated with a proapoptotic endothelial progenitor cell phenotype.Journal of vascular research · 2011Article
- Human aging and CD31+ T-cell number, migration, apoptotic susceptibility, and telomere length.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Central Arterial Aging and Angiotensin II Signaling.Current hypertension reviews · 2010Article
- Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin.European journal of endocrinology · 2010Article
- Ageing and endothelial progenitor cell release of proangiogenic cytokines.Age and ageing · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTelomere length declines with age in mature endothelial cells and is thought to contribute to endothelial dysfunction and atherogenesis. Bone marrow-derived circulating endothelial progenitor cells (EPCs) are critical to vascular health as they contribute to both reendothelialization and neovascularization. We tested the hypothesis that EPC telomere length decreases with age in healthy adult humans.
methodsPeripheral blood samples were collected from 40 healthy, non-obese, sedentary men: 12 young (age 21-34 years), 12 middle-aged (43-55 years) and 16 older (57-68 years). Putative EPCs were isolated from peripheral blood mononuclear cells and telomere length was determined using genomic DNA preparation and Southern hybridization techniques.
resultsEPC telomere length (base pairs) was approximately 20% (p=0.01) lower in the older (8492+523 bp) compared to the middle-aged (10,565+572 bp) and young (10,205+501 bp) men. Of note, there was no difference in EPC telomere length between the middle-aged and young men.
conclusionsThese results demonstrate that EPC telomere length declines with age in healthy, sedentary men. Interestingly, telomere length was well preserved in the middle-aged compared to young men, suggesting that EPC telomere shortening occurs after the age of 55 years.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.